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MicroRNA mediated signaling and metabolic reprogramming in oral squamous cell carcinoma

Gunjankumari Patel1, Sitaram Harihar2

  • 1Department of Experimental Surgery, McGill University, 1650 Cedar Avenue, T5-110, Montreal, QC, H3G 1A4, Canada.

Medical Oncology (Northwood, London, England)
|February 6, 2026
PubMed

Insights

This review explores microRNAs (miRNAs) in Oral Squamous Cell Carcinoma (OSCC), focusing on their role in metabolic reprogramming. Understanding these miRNAs can improve early detection and treatment strategies for this aggressive oral cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Oral Squamous Cell Carcinoma (OSCC) is an aggressive cancer with poor survival rates due to metastasis and recurrence.
  • Dysregulated signaling pathways drive OSCC progression, affecting tumor growth, proliferation, and resistance to cell death.
  • Aberrant signaling is crucial for metabolic adaptation in OSCC, enabling tumors to thrive in various microenvironments.

Purpose of the Study:

  • To review the role of specific microRNAs (miRNAs) in Oral Squamous Cell Carcinoma (OSCC).
  • To highlight how miRNAs modulate signaling pathways involved in metabolic reprogramming within OSCC tumors.
  • To identify miRNAs as potential diagnostic indicators and predictors of disease progression in OSCC.

Main Methods:

  • Literature review of studies on miRNAs and signaling pathways in OSCC.
  • Analysis of miRNA expression patterns and their regulatory functions.
  • Focus on the link between miRNA-mediated signaling and metabolic adaptation in oral cancer.

Main Results:

  • Multiple miRNAs regulate key signaling cascades in OSCC by controlling gene expression.
  • Specific miRNA expression in OSCC tumors correlates with diagnostic potential and disease progression.
  • miRNAs play a significant role in the metabolic conditioning of OSCC tumors.

Conclusions:

  • miRNAs are critical regulators of signaling pathways in OSCC, influencing tumor behavior and metabolic adaptation.
  • miRNA profiling holds promise for early detection and prognosis of Oral Squamous Cell Carcinoma.
  • Targeting miRNA-mediated signaling pathways may offer novel therapeutic strategies for OSCC.
Keywords:
MetabolismOSCCOral cancerReprogrammingSignalingmiRNA

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