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Related Concept Videos

Elasticity01:12

Elasticity

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Elasticity is the ability of an object to withstand the effects of distortion and to return to its original size and shape once the forces causing deformation are removed. When an elastic material deforms under the action of an external force, it experiences internal resistance to the deformation. However, if no external force is applied, it returns to its original state.
The elasticity of an object can be described by a stress-strain curve, which represents the relationship between stress...
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Elasticity in Concrete01:20

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Upon subjecting concrete to moderate or high uniaxial compressive or tensile stresses, the strain response is non-linear relative to the stress applied. As the stress is removed, the resulting stress-strain curve deviates from the original path traced during loading, creating a hysteresis loop, indicative of the concrete's non-linear and non-elastic properties. Typically, a material's modulus of elasticity, which is a measure of the material's stiffness, is inferred from the linear...
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Elastic Potential Energy01:01

Elastic Potential Energy

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Elastic potential energy is the energy stored as a result of the deformation of an elastic object, such as the stretching of a spring. An object is elastic if it returns to its original shape and size after being deformed. 
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Strain and Elastic Modulus01:15

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The quantity that describes the deformation of a body under stress is known as strain. Strain is given as a fractional change in either length, volume, or geometry under tensile, volume (also known as bulk), or shear stress, respectively, and is a dimensionless quantity. The strain experienced by a body under tensile or compressive stress is called tensile or compressive strain, respectively. In contrast, the strain experienced under bulk stress and shear stress is known as volume and shear...
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Elastic Collisions: Introduction01:00

Elastic Collisions: Introduction

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An elastic collision is one that conserves both internal kinetic energy and momentum. Internal kinetic energy is the sum of the kinetic energies of the objects in a system. Truly elastic collisions can only be achieved with subatomic particles, such as electrons striking nuclei. Macroscopic collisions can be very nearly, but not quite, elastic, as some kinetic energy is always converted into other forms of energy such as heat transfer due to friction and sound. An example of a nearly...
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Elastic Collisions: Case Study01:15

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Elastic collision of a system demands conservation of both momentum and kinetic energy. To solve problems involving one-dimensional elastic collisions between two objects, the equations for conservation of momentum and conservation of internal kinetic energy can be used. For the two objects, the sum of momentum before the collision equals the total momentum after the collision. An elastic collision conserves internal kinetic energy, and so the sum of kinetic energies before the collision equals...
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A Recombinant Elastic Peptide Rescues Elasticity From a Self-Assembled Dermal Sheet Model Treated With Ascorbic Acid.

Chloé Chave1,2, Jorgan Guard1, Thibault Massias1

  • 1Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique, UMR5305 CNRS/Université Claude Bernard Lyon 1, Lyon, France.

Experimental Dermatology
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Summary

A synthetic elastic protein (SEP) enhances elastic fiber formation in engineered skin, counteracting ascorbic acid

Keywords:
elasticityelastinfibroblaststissue engineeringtype I collagen

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Dermatology

Background:

  • The skin's extracellular matrix (ECM), composed of collagen and elastin, dictates tissue structure and function.
  • ECM imbalances in dermal substitutes compromise mechanical properties and physiological relevance.
  • Ascorbic acid (AA) negatively impacts elastic fiber biosynthesis in tissue engineering.

Purpose of the Study:

  • To evaluate a synthetic elastic protein (SEP) for improving ECM remodeling in dermal substitutes.
  • To restore collagen and elastin equilibrium in reconstructed skin tissues.
  • To investigate SEP's efficacy in conjunction with ascorbic acid.

Main Methods:

  • Fibroblast cultures treated with varying SEP concentrations, with or without AA.
  • Western blot and immunofluorescence to assess protein expression and localization.
  • Ultrastructural analysis of 3D dermal substitutes.
  • Dynamic mechanical analysis of decellularized ECM.

Main Results:

  • SEP promoted elastic fiber formation despite the presence of AA, which normally inhibits elastin synthesis.
  • SEP did not impede type I collagen assembly.
  • Ultrastructural analysis revealed SEP colocalization with fibrillin-rich fibrils in 3D constructs.
  • Mechanical testing showed significant increases in elastic (46%) and Young's moduli (40%) with SEP treatment.

Conclusions:

  • SEP effectively restores ECM integrity and balances collagen and elastin in engineered skin.
  • SEP demonstrates potential as a biomimetic tool for developing advanced 3D skin substitutes.
  • SEP application may enhance the physiological relevance and therapeutic efficacy of engineered skin tissues.