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Updated: Feb 8, 2026

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
Published on: April 27, 2015
Early impact of lenvatinib on liver function and its prognostic significance: a single-center retrospective study
Pei Wang1, Shuheng Liu2, Xiaoxia Lu1
1Department of Digestive Medicine, Wuwei People's Hospital, Wuwei City, People's Republic of China.
Objective:
Lenvatinib shows efficacy for tumor response and survival in patients with advanced hepatocellular carcinoma (HCC). We aim to assess the effect of lenvatinib on liver function.
Methods:
This single-center retrospective cohort study included 40 patients with advanced HCC who received ≥ 2 months of lenvatinib treatment from January 2020 to January 2024 and had at least one efficacy and safety assessment.
Results:
The ALBI score showed a slight but significant increase of 0.112 points, from -2.517 at baseline to -2.405 following 2-month of treatment (P < 0.05). With a median follow-up of 18.5 months, the median overall survival was 22.8 months (95% CI: 16.3-29.3), and the median progression-free survival was 12.7 months (95% CI: 9.1-16.3). Both COX regression and Kaplan-Meier analyses indicated that impaired baseline liver function was associated with adverse clinical outcomes. Additionally, treatment response emerged as an independent prognostic factor.
Conclusions:
The baseline ALBI score serves as a key prognostic marker, highlighting the necessity for meticulous monitoring of hepatic function, particularly in patients with compromised baseline liver reserve.
Limitations:
The limitations of this study include its retrospective design and the potential for selection bias arising from the requirement for at least 2 months of treatment.
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