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Updated: Feb 8, 2026

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke
Published on: February 10, 2023
NIR-II-Responsive Biomimetic Nanoplatform for Precise Inhibition of Ischemic Stroke via Dual Modulation of Ion
Xiaoning Liu1, Zhenghui Wu2, Honggui Lv3
1School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300401, China.
Abstract:
Ischemic stroke, a predominant cause of global mortality and disability, is characterized by a complex pathological cascade, following cerebral ischemia. Despite some progress in current conventional therapies and light-responsive nanosystems, there remains a lack of precise treatment strategies. Notably, the function of ion channels has attracted considerable attention due to its close association with the pathogenesis of ischemic stroke. Consequently, developing near-infrared (NIR)-responsive nanoplatforms for the targeted modulation of ion channels allows for a more precise treatment of ischemic stroke. Herein, a second NIR window (NIR-II) photothermal responsiveness nanoplatform (MNPs@Mi), camouflaged with a 4T1 cell membrane (CM) for targeted delivery, is designed to synergistically modulate microglial polarization and ion channel activity in the ischemic region. In a mouse model of distal middle cerebral artery occlusion (dMCAO), this integrated nanoplatform significantly shifts microglial polarization from the pro-inflammatory M1 to anti-inflammatory M2 phenotype, enhances neuronal survival, restores blood-brain barrier (BBB) integrity, and improves motor functional recovery. Quantitative analyses reveal a 2.3-fold increase in NeuN-positive cells and a 51.1% reduction in intracerebral IgG extravasation compared to those in the injury model group. Overall, this biomimetic NIR-II-responsive nanoplatform provides a noninvasive, spatiotemporally precise strategy for the treatment of ischemic stroke via the coordinated regulation of ion channels and microglial polarization.
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