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Updated: Feb 9, 2026

Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications
Published on: May 17, 2022
Recent advances in plant polyphenol-based adhesive hydrogels for biomedical applications
Yajun Chen1, Xue Guo2, Yuxin Zhang2
1Suzhou Institute of Trade & Commerce, Suzhou, 215009, People's Republic of China.
Abstract:
Plant polyphenol-based hydrogels have gained widespread attention due to their unique and outstanding properties such as adhesion, antibacterial, self-healing and biocompatibility. The adhesion performance of these hydrogels can be systematically engineered to meet specific requirements, demonstrating significant potential in biomedical applications. This review initially explores the design strategies of hydrogels derived from different plant polyphenols. Subsequently, the multiple adhesive properties imparted by diverse design strategies, including dry adhesion, underwater adhesion, switchable adhesion, specific adhesion and asymmetrical adhesion are discussed. In addition, biomedical applications of plant polyphenol-based adhesive hydrogels, focusing on wound dressings, therapeutic drug delivery, cartilage tissue scaffolds and wearable electronics are summarized. In the end, remaining challenges and outline prospects for future research are discussed. It is hoped that this review can provide new innovation into the development of plant polyphenol-based adhesive hydrogels.
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