Related Experiment Video
Updated: Feb 9, 2026
05:55
Modeling the Functional Network for Spatial Navigation in the Human Brain
Published on: October 13, 2023
1.6K
Single-cell resolution functional networks during unconsciousness are segregated into spatially intermixed modules.
Daiki Kiyooka1, Ikumi Oomoto2, Jun Kitazono3
1Department of General Systems Studies, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.
Cell Reports
|February 7, 2026
Summary
Consciousness reduction during sleep and anesthesia shows scale-dependent brain network organization. Network segregation differs at single-cell versus mesoscale levels, challenging previous views.
Area of Science:
- Neuroscience
- Systems Neuroscience
- Computational Neuroscience
Background:
- The neural basis for consciousness reduction during sleep and anesthesia is poorly understood.
- Limited spatial resolution in prior studies hindered exploring critical spatial scales of consciousness reduction.
Purpose of the Study:
- To investigate neural network organization across different spatial scales during reduced consciousness.
- To compare network structure during awake, sleeping, and anesthetized states in mice.
Main Methods:
- Recorded calcium signals from ~10,000 neurons across cortical regions in mice.
- Utilized single-cell resolution and wide-field two-photon microscopy.
- Analyzed network structure at single-cell and mesoscale levels.
Main Results:
- At the single-cell scale, both sleep and anesthesia showed higher network modularity (segregated networks) than wakefulness.
- Single-cell modules were spatially intermixed across all states.
- At the mesoscale, modularity differences between states were inconsistent, with spatially localized modules.
Conclusions:
- Brain network organization during reduced consciousness is scale-dependent.
- Traditional views of widespread network segregation during unconsciousness are challenged.
- Multi-scale analysis reveals complex network dynamics during altered states of consciousness.
Related Concept Videos
01:25Network Function of a Circuit
863
Frequency response analysis in electrical circuits provides vital insights into a circuit's behavior as the frequency of the input signal changes. The transfer function, a mathematical tool, is instrumental in understanding this behavior. It defines the relationship between phasor output and input and comes in four types: voltage gain, current gain, transfer impedance, and transfer admittance. The critical components of the transfer function are the poles and zeros.
863
02:26Protein Networks
4.6K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.6K
02:26Protein Networks
2.9K
2.9K
01:49Law of Segregation
78.2K
When crossing pea plants, Mendel noticed that one of the parental traits would sometimes disappear in the first generation of offspring, called the F1 generation, and could reappear in the next generation (F2). He concluded that one of the traits must be dominant over the other, thereby causing masking of one trait in the F1 generation. When he crossed the F1 plants, he found that 75% of the offspring in the F2 generation had the dominant phenotype, while 25% had the recessive phenotype.
78.2K
01:16Segregation in Fresh Concrete
592
Segregation in fresh concrete is a phenomenon where the components of the concrete mix separate, leading to uneven distribution and compromised structural integrity. This separation typically occurs when concrete is subjected to excessive horizontal movement within forms, or when it is dropped from considerable heights or forced through narrow, winding paths. As a result, heavier coarse aggregate particles settle at the bottom, while lighter, finer materials such as cement and water rise to the...
592
02:18Network Covalent Solids
16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K