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Updated: Feb 9, 2026
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
The C-Reactive Protein-Albumin-Lymphocyte (CALLY) index and all-cause mortality in adults with Asthma: A cohort study
Wen Luo1, Zhenzhen Yu2, Yongcai Zhang3
1Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361000, China.
Background:
Systemic inflammation, nutritional depletion, and immune dysregulation are common in asthma, yet no composite indicator has been prospectively linked to long-term survival; accordingly, the association between the C-Reactive Protein-Albumin-Lymphocyte (CALLY) index and all-cause mortality in U.S. adults with asthma was examined.
Methods:
We analyzed 3887 asthma participants aged ≥18 years from the National Health and Nutrition Examination Survey (NHANES) 1999-2010, linked to the National Death Index (NDI) through December 2019. Cox regression estimated hazard ratios (HR) per CALLY quartile and per one-unit increase in In-transformed CALLY, adjusting for sociodemographic, lifestyle and comorbidity covariates. Non-linearity was assessed with restricted cubic splines; subgroup analyses tested effect consistency.
Results:
During a median 157 months, 729 deaths occurred (18.8% mortality). Higher CALLY was associated with younger age, lower BMI and fewer comorbidities. After full adjustment, each unit increase in CALLY conferred a 19% lower mortality risk (HR 0.81, 95 % CI 0.76-0.86). The dose-response gradient remained linear across the entire distribution, and the inverse association was consistently observed across all predefined strata.
Conclusion:
In this cohort, a higher CALLY index was independently associated with lower all-cause mortality among adults with asthma; prospective studies are warranted to confirm this association.
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