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Updated: Feb 9, 2026

Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
Visual quality evaluation of topography-guided FS-LASIK based on phorcides for myopia and astigmatism
Caiyun Fu1, Mingshen Sun1, Fengju Zhang1
1Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Objective:
To evaluate the clinical outcomes and visual quality after Phorcides planned Contoura topography-guided femtosecond laser-assisted excimer laser in situ keratomileusis (TOPO-G FS-LASIK) for myopia and astigmatism correction.
Methods:
Non-randomized retrospective study. 38 eyes in the high ocular residual astigmatism (HORA, >0.75D) group and 44 eyes in the low ocular residual (LORA, <0.75D) group were treated, and the accuracy was evaluated based on the Phorcides planned Contoura TOPO-G FS-LASIK. Routine examinations and specific tests, such as ocular aberrations, optical quality analysis system, a subjective visual quality questionnaire, and contrast sensitivity (CS), were measured and compared within and between groups preoperatively and postoperatively.
Results:
At 6 m postoperatively, manifest refractive spherical equivalent, uncorrected and corrected distance visual acuity, safety index, effectivity index, target-induced astigmatism, surgical-induced astigmatism, difference vector, angle of error, and correction index were similar in both HORA and LORA groups (P > 0.05). Objective scatter index, modulation transfer function cut-off, visual acuity (VA) 100%, and all the CS were similar between the two groups preoperatively and postoperatively (P > 0.05). But VA20%/9%, Strehl ratio, the CS of 1.5/3/6/12/18c/d in the HORA group, and 1.5/3/6c/d in the LORA group were significantly elevated 6 m postoperatively. The subjective visual quality questionnaire scores were consistent both within and between groups preoperatively and 6 m postoperatively.
Conclusions:
Phorcides planned Contoura TOPO-G FS-LASIK achieved the predicted outcomes, demonstrating objective and universal applicability. Visual quality in the HORA group was significantly improved, especially the night vision and high-frequency spatial CS.
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