Trends in non-syndromic cleft lip and palate research: A bibliometric analysis

Non-syndromic cleft lip and palate (NSCLP) is one of the most common congenital craniofacial anomalies. This study aims to systematically evaluate the developmental trends and research frontiers in NSCLP research using bibliometric analysis.

NSCLP-related articles published in English between January 1982 and February 2025 were retrieved from the Web of Science Core Collection database. VOSviewer, CiteSpace, and R package "bibliometrix" were used to evaluate publication trends, citation patterns, collaborative networks, and keyword evolution.

A total of 1,068 eligible articles were analyzed. The United States (254 articles, 11,488 citations) was the most productive countries, with the University of Iowa being the most active institution. Mary L. Marazita (H-index 25) was the most influential researchers. Keyword analysis revealed five distinct research clusters: genetic mechanisms, clinical phenotypes, epidemiological factors, genetic susceptibility, and developmental biology. Keyword burst analysis indicated that "prevalence" continues to exhibit a burst trend in 2025, with a link strength of 8.46.

This study employs bibliometric analysis to comprehensively map the landscape and developmental trajectory of NSCLP research, highlighting its key areas spanning basic mechanisms, clinical medicine, and epidemiology. The findings suggest that future research priorities are likely to remain focused on the epidemiological aspects of the disease.