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Updated: Feb 9, 2026

Murine Model of Central Venous Stenosis using Aortocaval Fistula with an Outflow Stenosis
Published on: July 11, 2019
Safety and Efficacy of Intracystic Fibrin Glue Injection for CSF-Venous Fistulas
Alexandre Bani-Sadr1,2, Apolline Guérin3, Caroline Froment Tilikete4
1From the Department of Neuroradiology (A.B.-S., A.G., Y.B.), East Group Hospital, Hospices Civils de Lyon, Lyon, France apbanisadr@gmail.com.
None:
We evaluated the safety and efficacy of CT-guided intracystic fibrin glue injection for CSF-venous fistulas (CVFs) causing spontaneous intracranial hypotension. In this 2-center retrospective series, 16 patients underwent fibrin injection directly into the diverticular cyst, with additional epidural or paravertebral injection as needed. Median intracystic fibrin volume was 1.0 mL; thecal sac extension was present in 44% of cases. No serious or permanent complications, arachnoiditis, or neurologic deficits were observed. Transient rebound intracranial hypertension occurred in 31% and transient radicular pain in 6%, both resolving spontaneously. Clinical outcomes were favorable, with 88% of patients reporting complete and 12% partial symptom improvement. The median Bern score decreased from 6.0 pretreatment to 0 posttreatment, and CT myelography in a subset confirmed fistula closure. CT-guided intracystic fibrin glue injection appears to be a safe, effective, and targeted option for CVF treatment, meriting further prospective evaluation.
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