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Updates on the Current and Evolving Treatment for Hereditary Angioedema
Paula J Busse1, Jie Shen Fok2, Sohini Shah Kamdar3
1Department of Medicine, Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY.
The Journal of Allergy and Clinical Immunology. in Practice
|February 7, 2026
Summary
Hereditary angioedema (HAE) treatments have evolved from limited options to targeted therapies. Newer HAE treatments significantly improve patient quality of life by reducing swelling episodes and disease severity.
Area of Science:
- Immunology
- Genetics
- Pharmacology
Background:
- Hereditary angioedema (HAE) with C1-inhibitor deficiency causes recurrent swelling.
- Traditional HAE treatments had significant side effects and limited efficacy.
- Advances in understanding HAE pathogenesis have driven therapeutic innovation.
Purpose of the Study:
- To review current and emerging treatments for hereditary angioedema (HAE).
- To highlight the impact of novel therapies on HAE management and patient outcomes.
- To discuss future directions in HAE treatment strategies.
Main Methods:
- Literature review of peer-reviewed articles and clinical trial data.
- Analysis of approved and investigational HAE therapies.
- Synthesis of information on acute and prophylactic treatment options.
Main Results:
- Newer targeted therapies offer improved efficacy and safety profiles for HAE.
- These advancements have led to reduced HAE-related morbidity and mortality.
- Quality of life for HAE patients has substantially improved with modern treatments.
Conclusions:
- Current HAE treatments represent a significant improvement over historical options.
- Ongoing research promises further advancements in HAE management.
- Personalized and effective HAE therapies are becoming increasingly available.
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