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Dengue serotypes and their severity correlation: A hospital-based observational study.
1Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Enfermedades Infecciosas Y Microbiologia Clinica (English Ed.)
|February 7, 2026
Summary
Dengue virus type 2 (DENV-2) is strongly linked to severe dengue and mortality in northern India. Identifying DENV serotypes and lab markers aids in managing severe dengue cases.
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Background:
- Dengue virus (DENV) infections exhibit varied clinical severity.
- Specific DENV serotypes may influence disease outcomes.
- Understanding serotype-disease correlation is crucial for clinical management.
Purpose of the Study:
- To identify circulating DENV serotypes in hospitalized patients.
- To assess the association between DENV serotypes and clinical outcomes.
- To determine predictors of severe dengue and mortality.
Main Methods:
- Retrospective, cross-sectional study of 356 laboratory-confirmed dengue cases.
- Serotyping performed using nested reverse transcription-polymerase chain reaction (nested RT-PCR).
- Analysis of demographic, clinical, and biochemical data; relative risk analysis.
Main Results:
- DENV-2 was the predominant serotype (71.2%), followed by DENV-3 (26.9%).
- Severe dengue occurred in 28.8% of patients, with highest rates in DENV-2 infections.
- DENV-2 significantly correlated with plasma leakage (RR=24.73) and mortality (21.6%).
Conclusions:
- DENV-2 is the primary serotype associated with severe dengue and mortality in this region.
- Early serotype identification and monitoring lab parameters improve risk stratification.
- Findings have implications for dengue surveillance and public health strategies.
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