Related Experiment Video
Updated: Feb 9, 2026
04:48
Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
Published on: November 22, 2024
881
Corneal Lymphoma in Humans: First Population-Based Evidence of Occurrence and Clinical Characteristics
Pierre Loap1, Youlia Kirova2, Remi Dendale3
1Department of Radiation Oncology, Institut Curie, Paris, France; Proton Therapy Center, Institut Curie, Orsay, France; Laboratoire d'Imagerie Translationnelle en Oncologie, Institut Curie, Orsay, France.
Clinical Lymphoma, Myeloma & Leukemia
|February 7, 2026
Summary
Corneal lymphoma, a rare human cancer, has been identified for the first time. This study describes its characteristics and suggests a favorable prognosis, particularly with radiotherapy for localized disease.
Area of Science:
- Ophthalmology
- Oncology
- Hematology
Background:
- Ocular lymphomas are documented in various eye structures, but primary corneal lymphoma has not been reported in humans.
- Previous reports of corneal lymphoma are limited to animals, primarily horses.
Purpose of the Study:
- To investigate the existence of primary corneal lymphoma in humans.
- To characterize the epidemiologic and clinical features of this rare condition.
Main Methods:
- A population-based retrospective analysis of the SEER 17 registries (2000-2022) was performed.
- Cases coded as C69.1 (cornea) were identified, and demographic, pathological, treatment, and survival data were extracted.
- Incidence rates were age-adjusted, and survival analysis was conducted.
Main Results:
- Five cases of strictly localized corneal lymphoma were identified, with an incidence of 0.0028 per million person-years.
- The mean age at diagnosis was 75 years, with a 4:1 male predominance; three cases were mucosa-associated lymphoid tissue (MALT) lymphomas.
- Patients received local surgery and radiotherapy for unilateral disease; two deaths occurred, with three patients surviving, including two long-term survivors.
Conclusions:
- Human corneal lymphoma is exceptionally rare and shares a favorable prognosis with other ocular MALT lymphomas.
- Radiotherapy may achieve durable disease control in localized corneal lymphoma.
- These findings establish corneal lymphoma as a human entity and advocate for increased diagnostic awareness in ocular oncology.
More Related Videos
Related Concept Videos
02:55The Evidence for Evolution
48.3K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.3K
01:23Characteristics of Life
262.3K
Biology is a natural science that studies life and living organisms, including their structure, function, development, interactions, evolution, distribution, and taxonomy. The field's scope is extensive and divided into several specialized disciplines, such as anatomy, physiology, ethology, genetics, and many more. All living things share a few key traits, including cellular organization, heritable genetic material and the ability to adapt/evolve, metabolism to regulate energy needs, the...
262.3K
01:21Types of Reports II: Incident or Occurrence Report
1.3K
An Incident or Occurrence Report in a healthcare setting is a crucial document used to record any unexpected occurrence that may or may not have affected a patient, employee, or visitor. Such reports are critical to improving patient safety and include all details leading up to and including the event.
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
1.3K
02:04Conservation of Small Populations
17.4K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
17.4K
01:25What is Population Genetics?
64.8K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.8K
00:57Population Growth
28.7K
Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
28.7K