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Peripheral retinal lesions in highly myopic children: prevalence, types and biometric correlates
Jacques Bijon1, Louise Brach1, Etienne Boulanger1
1French Institute of Myopia, Adolphe de Rothschild Foundation Hospital, Paris, France.
Insights
Peripheral retinal lesions are common in children with high myopia, with over half affected. Axial length is the strongest predictor, highlighting the need for early screening in pediatric high myopia.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Retinal Imaging
Background:
- High myopia in children is associated with significant ocular complications.
- Peripheral retinal lesions are a known risk factor for retinal detachment.
Purpose of the Study:
- To determine the prevalence, types, and biometric predictors of peripheral retinal lesions in children with high myopia.
- To assess the relationship between axial length and peripheral retinal lesions in this population.
Main Methods:
- Retrospective cross-sectional study of 89 children (aged 4-17 years) with high myopia.
- Peripheral retinal evaluation using ultra-widefield imaging and/or dilated ophthalmoscopy.
- Analysis of biometric data, including axial length and refractive error.
Main Results:
- Peripheral retinal lesions were found in 54.4% of eyes, increasing with age.
- The most common lesions included dark without pressure, white without pressure, and snail-track degeneration.
- Axial length was the strongest independent predictor of lesion prevalence (OR=1.45) and multiplicity (OR=2.17).
Conclusions:
- Peripheral retinal lesions are highly prevalent in pediatric high myopia and strongly correlated with axial length.
- Early peripheral retinal assessment, particularly using ultra-widefield imaging, is crucial for risk stratification and surveillance in high myopic children.
Aims:
To evaluate prevalence, types and biometric predictors of peripheral retinal lesions in highly myopic children.
Methods:
Retrospective cross-sectional study at a tertiary centre. Participants were aged 4-17 years with high myopia (≤-4.00 dioptres (D) at 4-6 years; ≤-6.00 D at 7-17 years). Peripheral retina was assessed by ultra-widefield imaging (UWF) and/or documented dilated ophthalmoscopy.
Results:
We analysed 160 eyes from 89 children (mean age 10.4±3.8 years; mean spherical equivalent -9.95±3.59 D; mean axial length (AL) 26.68±1.82 mm). Peripheral lesions were present in 87/160 eyes (54.4%), more frequent in 7-17-year-olds than in 4-6-year-olds (59.4% vs 34.4%) (p<0.05). Among affected eyes, 50/87 (57%) had a single lesion and 37/87 (43%) multiple; multiplicity increased with age (p<0.001). The most frequent lesions were dark without pressure (46/160; 28.7%), white without pressure (32/160; 20.0%), snail-track degeneration (15/160; 9.4%), microcystoid degeneration (11/160; 6.9%) and lattice degeneration (10/160; 6.3%). In multivariate models, AL was the strongest independent predictor of both lesion prevalence (OR=1.45; 95% CI 1.07 to 2.03; p=0.021) and multiplicity (OR=2.17; 95% CI 1.53 to 3.07; p<0.001). Model-derived lesion probability reached 50% at AL 26.2 mm and 80% at 29.4 mm.
Conclusions:
Peripheral retinal lesions are common in paediatric high myopia and related strongly to AL. Early peripheral retinal assessment using UWF imaging or thorough dilated examination may enhance risk stratification and surveillance.
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