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Updated: Feb 10, 2026

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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
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ACT-based change processes as predictors of post-stroke depression among stroke survivors
Eden Henderson-Roe1, James Elander1, Paul Staples1
1School of Psychology, University of Derby, Derby, UK.
Neuropsychological Rehabilitation
|February 8, 2026
Summary
Acceptance and Commitment Therapy (ACT) interventions can help stroke survivors reduce depression. Targeting cognitive fusion, a process of ACT, is key to improving mental health after stroke.
Area of Science:
- Psychology
- Neurorehabilitation
- Clinical Psychology
Background:
- Stroke survivors frequently experience depression, necessitating targeted interventions.
- Acceptance and Commitment Therapy (ACT) offers potential mechanisms for addressing depression in this population.
- Understanding specific contextual-behavioural change processes is crucial for optimizing ACT-based interventions.
Purpose of the Study:
- To investigate the relationship between psychological flexibility, cognitive fusion, valued living, stroke impact, and depression in stroke survivors.
- To identify key change processes within ACT that can be targeted to reduce depression post-stroke.
- To examine the mediating role of cognitive fusion in the association between psychological flexibility and depression.
Main Methods:
- An online questionnaire survey was administered to 81 stroke survivors.
- Measures included depression (PHQ-9), psychological flexibility (AAQ-ABI), cognitive fusion (CFQ), valued living (VLQ), and stroke impact (SF-SIS).
- Hierarchical linear regression and mediation analyses were employed to analyze the data.
Main Results:
- Cognitive fusion, stroke impact, gender, and ethnicity independently predicted depression, explaining 60.2% of the variance.
- Cognitive fusion significantly mediated the relationship between psychological flexibility and depression.
- Psychological flexibility's impact on depression was largely explained by its effect on cognitive fusion.
Conclusions:
- ACT-based interventions show promise for reducing depression in stroke survivors.
- Cognitive de-fusion emerges as a critical targetable change process for mitigating post-stroke depression.
- Cognitive de-fusion may aid in rebuilding personal identity, thereby positively impacting depression levels.
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