Second Asian Consensus Report on Functional Dyspepsia (2025): Updated Recommendations.

Area of Science:

• Gastroenterology
• Clinical Practice Guidelines
• Digestive Health

Background:

• Functional dyspepsia (FD) is a prevalent gastrointestinal condition impacting patient quality of life.
• Previous Asian consensus reports on FD were established over a decade ago by ANMA and APAGE.
• This report focuses on Asian populations, addressing FD definition, diagnosis, epidemiology, pathophysiology, and management.

Purpose of the Study:

• To provide updated, evidence-based recommendations for the diagnosis and management of functional dyspepsia (FD).
• To focus specifically on the Asian population, considering regional epidemiological and clinical characteristics.
• To incorporate recent advancements in understanding FD pathophysiology and treatment.

Main Methods:

• A systematic literature review was performed by a task force.
• A modified Delphi process was employed to develop consensus statements.
• Statements were revised based on member feedback and subgroup voting to achieve at least 80% consensus.

Main Results:

• Thirty-two consensus statements covering key aspects of FD were developed.
• New insights into FD pathophysiology and emerging treatment options were identified.
• Limitations in current research were acknowledged, particularly regarding novel therapies like probiotics and potassium-competitive acid blockers.

Conclusions:

• The second Asian Consensus Report on FD offers updated recommendations for clinical practice.
• These guidelines aim to enhance the diagnosis and management of FD in Asian patients.
• The report emphasizes evidence-based strategies tailored to the Asian context.