Steroid-induced Hypokalemic Periodic Paralysis

Hypokalemic periodic paralysis (HypoPP) occurs in calcium and sodium ion channelopathy, which is a rare presentation following certain triggers. This typically hereditary condition leads to episodic acute muscle weakness associated with hypokalemia, which can later present as permanent weakness. This article presents the case of a 37-year-old male who developed bilateral lower limb weakness associated with severe hypokalemia following intramuscular administration of 8 mg dexamethasone. HypoPP, though not common, should be evaluated in patients following treatment with glucocorticoids. These patients present with typical symptoms that can be managed accordingly.