Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Load-frequency control01:28

Load-frequency control

679
Load-frequency control (LFC) is vital for maintaining power system stability, ensuring that frequency and power flows remain within acceptable limits during load changes. Turbine-governor control eliminates rotor accelerations and decelerations following load changes. However, a steady-state frequency error persists when the change in the turbine-governor reference setting is zero. In an interconnected power system, each area agrees to export or import a scheduled amount of power through...
679
Antibiotic Selection00:57

Antibiotic Selection

60.1K
Overview
60.1K
Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

711
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
711
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.5K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.5K
Energy-releasing Steps of Glycolysis01:28

Energy-releasing Steps of Glycolysis

147.1K
Glycolysis is divided into two phases based on whether energy is utilized or released. While the first phase consumes ATP, the second phase produces energy in the form of ATP and NADH. The energy is released over a sequence of reactions that turns G3P into pyruvate. The energy-releasing phase—steps 6-10 of glycolysis—occurs twice, once for each of the two 3-carbon sugars produced during steps 1-5 of the first phase.
The first energy-releasing step—the 6th step of glycolysis...
147.1K
Impact Loading01:19

Impact Loading

713
Impact loading occurs when a moving object collides with a stationary structure, such as a rod with a uniform cross-sectional area fixed at one end. Under these conditions, the rod absorbs the kinetic energy from the striking object, leading to deformation and subsequent stress development. As the rod returns to its original position and reaches maximum stress, the absorbed energy, initially manifested as kinetic energy, transforms entirely into strain energy.
In cases of elastic deformation,...
713

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deficit in blood MAIT cells, altered cytokines and T cell dynamics in patients with coronary artery disease.

Cellular immunology·2026
Same author

Ultrasound-responsive composite hydrogels: Design rules for spatiotemporally controlled drug delivery.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Assessment of Early Breast Cancer Response to Chemotherapy with Ultrasound Radiomics.

Diagnostics (Basel, Switzerland)·2026
Same author

Real-time drug release monitoring from acoustically responsive scaffolds.

Ultrasonics sonochemistry·2026
Same author

2025 International Consensus Meeting on Musculoskeletal Infection: Summary From Biofilm Workgroup on Treatment of Biofilm-Related Infection and Preclinical Models.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026
Same author

Infective Endocarditis-Impact of Preoperative Neurological Complications on Postoperative Outcome.

European journal of neurology·2026

Related Experiment Video

Updated: Feb 10, 2026

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
04:09

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing

Published on: December 13, 2024

1.4K

Controlled Antibiotic Release From Emulsion-Loaded Alginate and Fibrin Hydrogels Using Ultrasound.

Ziba Ghareh Nazi Fam1, Asia Winslow2, Mario L Fabiilli3

  • 1Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Journal of Biomedical Materials Research. Part A
|February 9, 2026
PubMed
Summary

This study introduces a novel hydrogel for sustained and ultrasound-triggered vancomycin (VAN) release, improving infection prevention after spinal fusion surgery by providing prolonged antibiotic coverage.

Keywords:
alginatecontrolled releasefibrinphase‐shift emulsionsultrasound

More Related Videos

Encapsulation of Cardiomyocytes in a Fibrin Hydrogel for Cardiac Tissue Engineering
10:18

Encapsulation of Cardiomyocytes in a Fibrin Hydrogel for Cardiac Tissue Engineering

Published on: September 19, 2011

26.0K
Author Spotlight: Exploring the Potential of Fat-Derived Stromal Vascular Fraction for Wound Healing
05:30

Author Spotlight: Exploring the Potential of Fat-Derived Stromal Vascular Fraction for Wound Healing

Published on: November 17, 2023

1.1K

Related Experiment Videos

Last Updated: Feb 10, 2026

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
04:09

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing

Published on: December 13, 2024

1.4K
Encapsulation of Cardiomyocytes in a Fibrin Hydrogel for Cardiac Tissue Engineering
10:18

Encapsulation of Cardiomyocytes in a Fibrin Hydrogel for Cardiac Tissue Engineering

Published on: September 19, 2011

26.0K
Author Spotlight: Exploring the Potential of Fat-Derived Stromal Vascular Fraction for Wound Healing
05:30

Author Spotlight: Exploring the Potential of Fat-Derived Stromal Vascular Fraction for Wound Healing

Published on: November 17, 2023

1.1K

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Orthopedic Surgery

Background:

  • Postoperative infections are a significant complication following spinal fusion surgery, often due to antibiotic-resistant bacteria.
  • Current short-term antibiotic prophylaxis and local vancomycin (VAN) delivery are insufficient for preventing late-onset infections due to rapid drug level decline.

Purpose of the Study:

  • To develop a composite hydrogel system for sustained and ultrasound-triggered release of vancomycin (VAN).
  • To evaluate the drug release kinetics and antibacterial efficacy of the developed hydrogel against Staphylococcus aureus.

Main Methods:

  • Fabrication of water-in-oil-in-water emulsions using perfluorohexane and embedding them within alginate or fibrin hydrogels.
  • Quantification of VAN release using spectrophotometry and fluorescent labeling.
  • Assessment of antibacterial activity against Staphylococcus aureus, with and without ultrasound stimulation.

Main Results:

  • Emulsion-loaded hydrogels significantly reduced premature VAN leakage compared to directly loaded hydrogels, showing >70% retention on Day 1.
  • Ultrasound application triggered significant VAN release, increasing drug delivery up to 8.75-fold in alginate and 27.5-fold in fibrin hydrogels after 7 days.
  • Alginate-emulsion hydrogels demonstrated measurable antibacterial activity, enhanced significantly by ultrasound treatment (p < 0.05).

Conclusions:

  • The developed composite hydrogel platform enables dual-mode VAN delivery, offering both sustained baseline release and on-demand, ultrasound-triggered reinforcement.
  • This system provides spatial and temporal control over drug release, potentially improving infection prevention strategies in orthopedic surgeries.
  • Alginate-based hydrogels show promise for effective VAN delivery and antibacterial action, aligning drug release with clinical needs for prolonged coverage.