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Related Experiment Video

Updated: Feb 10, 2026

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Published on: September 26, 2017

Organ-on-a-Chip Fabrication Using Dynamic Photomask.

Terry Ching^1,2,3,4, Shu-Yung Chang^1,2, Takanobu Takenouchi^1,5

¹Pillar of Engineering Product Development, Singapore University of Technology and Design, Singapore, 487372, Singapore.

|February 9, 2026

Summary

This summary is machine-generated.

A new system fabricates organ-on-a-chip (OoC) devices using digital photopatterning, speeding up innovation. This method allows for complex designs and real-time modifications, accelerating OoC technology adoption for research.

Keywords:

bioprinting microfluidics organ‐on‐a‐chip tissue engineering vascularization

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Fabrication of Fine Electrodes on the Tip of Hypodermic Needle Using Photoresist Spray Coating and Flexible Photomask for Biomedical Applications

Published on: November 28, 2017

Area of Science:

Biomedical Engineering
Microfluidics
Tissue Engineering

Background:

Organ-on-a-chip (OoC) technology offers physiologically relevant microscale models for biomedical studies.
Current fabrication methods, primarily soft lithography, present a bottleneck due to long design-to-prototype cycles.
Accelerating OoC innovation requires more agile fabrication processes.

Purpose of the Study:

To develop a versatile system for fabricating OoC devices with increased agility.
To overcome the limitations of traditional soft lithography in OoC development.
To enable rapid prototyping and customization of OoC for diverse research needs.

Main Methods:

A novel system combining xurography for microchambers and digital photomask photopatterning for microfluidic channels.
Direct photopatterning approach for OoC fabrication.
Integration of a digital photomask with a microchamber system.

Main Results:

Achieved previously unattainable features in OoC fabrication, including non-reticular height profiles.
Enabled real-time modification of channel designs for applications like spheroid trapping.
Demonstrated a versatile system accommodating various microenvironment design requirements.

Conclusions:

The developed system facilitates rapid fabrication of OoC devices through direct photopatterning.
This approach can accelerate OoC design innovation and adoption in the scientific community.
Potential to advance therapeutic screening and disease mechanism elucidation using custom OoC models.