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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Tumor Progression02:07

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Cancer Stem Cells and Tumor Maintenance02:40

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Loss of Tumor Suppressor Gene Functions01:12

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Related Experiment Video

Updated: Feb 10, 2026

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)
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Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

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[IKZF3/Aiolos and tumors].

Qi Jia1,2, Kangmei Shao3, Yangrun Li4

  • 1Department of Surgical Oncology, Second Hospital of Lanzhou University, Lanzhou 730000. 1223684838@qq.com.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|February 9, 2026
PubMed
Summary

The IKZF3 gene, encoding Aiolos protein, is crucial for lymphocyte function and shows high expression in tumors. Its role in tumor progression and drug resistance highlights IKZF3 as a potential therapeutic target.

Keywords:
Ikaros family zinc finger 3drug resistanttargeted therapytumortumor microenvironment

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Area of Science:

  • Molecular biology
  • Oncology
  • Immunology

Background:

  • Aiolos, a protein encoded by the IKZF3 gene, is vital for lymphocyte differentiation and proliferation.
  • Abnormally high Aiolos expression is observed in early-stage tumors, suggesting a role in cancer development.
  • IKZF3 gene alterations impact tumor therapy, drug resistance, and patient outcomes.

Purpose of the Study:

  • To systematically review the latest research on the IKZF3 gene.
  • To elaborate on its structure, physiological functions, and role in tumor regulation.
  • To discuss its implications in treatment resistance and potential as a therapeutic target.

Main Methods:

  • Literature review of scientific articles on IKZF3 and cancer.
  • Analysis of studies detailing signaling pathways regulated by Aiolos.
  • Synthesis of information regarding gene instability and therapeutic resistance.

Main Results:

  • Aiolos regulates tumor invasion and metastasis via pathways including p66Shc, PI3K/Akt/Twist, c-Myc, IRF4, BCR, and NF-κB.
  • IKZF3 gene instability affects drug resistance and patient prognosis in various cancers.
  • High IKZF3 expression correlates with early tumor development.

Conclusions:

  • IKZF3 serves as a significant biological indicator for tumors.
  • The IKZF3 gene presents a promising new therapeutic target for cancer treatment.
  • Further research into IKZF3 can inform future cancer therapies.