Related Experiment Video
Updated: Feb 10, 2026

High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease
Published on: October 31, 2012
Procalcitonin as a predictive biomarker for disease severity and prognosis in pediatric acute necrotizing
Kechun Li1, Lingzhi Liu2, Fei Li1
1Department of Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Background:
Procalcitonin (PCT) elevation has been observed in non-infectious conditions. This study aimed to investigate the relationship between early-stage PCT levels and prognosis of acute necrotizing encephalopathy (ANE) in children.
Methods:
We enrolled children diagnosed with ANE who were admitted to the pediatric intensive care unit of Beijing Children's Hospital and Henan Children's Hospital between January 1, 2018 and December 31, 2023. Patients were categorized into survival and non-survival groups based on their 28-day outcomes. The optimal early PCT cutoff value was determined using receiver operating characteristic (ROC) curve analysis.
Results:
A total of 74 children with ANE were included. Viral pathogens accounted for 79.7% (59/74) of infections. Antimicrobial therapy was initiated in 17 patients (23.0%, 17/74) at admission. The 28-day mortality rate was 55.4% (41/74). The optimal cutoff value of PCT was 3.55 ng/mL (area under the curve =0.689). The proportion of patients with shock at admission was significantly higher in the PCT >3.55 ng/mL group than the PCT ≤3.55 ng/mL group (45.7% vs. 21.4%, P=0.04). Multivariate logistic regression analysis revealed that PCT >3.55 ng/mL and shock at admission were independent risk factors for 28-day mortality (odds ratio =4.414, 95% confidence interval: 1.193-16.333, P=0.03; odds ratio =52.741, 95% confidence interval: 6.224-446.925, P<0.001).
Conclusions:
Early PCT >3.55 ng/mL was identified as an independent risk factor for 28-day mortality in children with ANE, and this should alert clinicians to the possibility of concurrent shock. The majority of PCT elevations were not attributable to bacterial infections in ANE patients.
More Related Videos
10:03Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
10:22Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
Published on: December 6, 2016
Related Concept Videos
Predicting Molecular Geometry
Prediction Intervals
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
Pharmacokinetics in Pediatric Patients: Drug Excretion
Sensitivity, Specificity, and Predicted Value
Sensitivity is the...
End Point Prediction: Gran Plot
For potentiometric titration, the Gran plot is created by plotting...
Predicting Reaction Outcomes