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Published on: September 16, 2012
Clinical Outcomes of Sonidegib in Vismodegib-Exposed Locally Advanced Basal Cell Carcinoma: Insights From a
Alvaro Prados-Carmona1,2, María Martínez-Pérez3, J Pablo Velasco-Amador1
1Department of Dermatology, Hospital Universitario San Cecilio, Granada, Spain, juntadeandalucia.es.
Background:
Locally advanced basal cell carcinoma represents a therapeutic challenge, especially if already exposed to hedgehog (Hh) pathway inhibitor (HPI) therapy. Effectiveness after switching to another HPI still requires exploration.
Methods:
This observational, descriptive study retrospectively evaluates the clinical outcomes of sonidegib in patients with vismodegib-treated locally advanced basal cell carcinoma in a real-world, multicenter cohort across nine centers. Twelve patients with histologically aggressive locally advanced basal cell carcinoma previously exposed to vismodegib for at least 3 months were analyzed. Each received sonidegib at a standard dosage. Treatment response was assessed clinically according to tumor size changes and classified as complete response (100% decrease), partial response (at least 50% decrease), stable disease (up to 20% increase or less than 50% decrease), or disease progression (at least 20% increase). Adverse events (AEs) were documented.
Results:
Two patients achieved complete clinical response, nine demonstrated partial response, and one exhibited disease progression. Disease control was achieved in 11 of the 12 patients (91.7%). No novel AEs have been documented, and they were managed through dose adjustments or temporary interruptions.
Conclusion:
These findings suggest that sonidegib could still show efficacy and may still serve as a viable second-line option after prior Hh pathway suspension.
Insights
Sonidegib shows efficacy as a second-line treatment for locally advanced basal cell carcinoma previously treated with vismodegib. Disease control was achieved in 91.7% of patients, indicating sonidegib
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Locally advanced basal cell carcinoma (BCC) presents treatment challenges, particularly after prior hedgehog (Hh) pathway inhibitor (HPI) therapy.
- The effectiveness of switching to a different HPI in such cases requires further investigation.
Purpose of the Study:
- To evaluate the clinical outcomes of sonidegib in patients with locally advanced BCC who previously received vismodegib.
- To assess sonidegib's efficacy as a second-line HPI therapy in a real-world setting.
Main Methods:
- Retrospective, observational, and descriptive study of 12 patients across nine centers.
- Patients had histologically aggressive locally advanced BCC and received vismodegib for ≥3 months.
- Sonidegib was administered at a standard dose; response was assessed by tumor size changes and adverse events (AEs) were documented.
Main Results:
- 11 out of 12 patients (91.7%) achieved disease control.
- Two patients had a complete response, and nine had a partial response.
- No new AEs were observed; management involved dose adjustments or interruptions.
Conclusions:
- Sonidegib demonstrates efficacy as a second-line treatment option for locally advanced BCC after prior Hh pathway inhibition.
- These findings support sonidegib's potential role in managing patients refractory to initial HPI therapy.
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