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Updated: Feb 10, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
Prognostic significance of CD44s expression in oral squamous cell carcinoma: An immuno-histo-chemical analysis
Hershita Singh1, Sandeep Sidhu2, Arun Bhardwaj3
1Department of Oral Pathology and Microbiology, National Dental College, DeraBassi, Mohali, Punjab, India.
Abstract:
Oral squamous cell carcinoma (OSCC) is a common malignancy with a poor prognosis, highlighting the need for reliable molecular biomarkers. CD44s, a cell adhesion molecule, has been implicated in tumor progression, but its prognostic role in OSCC is unclear. This retrospective study evaluated CD44s expression in 50 OSCC cases using immunohistochemistry and an immunoreactive scoring system. High CD44s expression significantly correlated with advanced stage, lymph node metastasis and poor histological grade. CD44s overexpression may serve as a prognostic biomarker to identify high-risk OSCC patients requiring aggressive therapy.
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