Related Experiment Video

Updated: Feb 10, 2026

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer
07:46

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer

Published on: August 17, 2010

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Natural compounds in ovarian cancer: mechanistic insights and therapeutic potential

Barathan Muttiah1, Nur Atiqah Haizum Abdullah2

  • 1Department of Medical Microbiology and Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Frontiers in Pharmacology
|February 9, 2026
PubMed

Insights

Natural compounds show promise in fighting ovarian cancer (OC) by inhibiting growth and overcoming chemoresistance. Future research should focus on delivery systems and personalized medicine for clinical success.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Ovarian cancer (OC) is a lethal gynecologic malignancy with high recurrence and chemoresistance.
  • Natural compounds (NCs) are increasingly recognized for their multi-targeted therapeutic potential in cancer.
  • NCs offer a promising avenue to enhance standard OC therapies.

Purpose of the Study:

  • To review the anticancer properties of various natural compounds against ovarian cancer.
  • To elucidate the molecular mechanisms underlying their efficacy.
  • To identify barriers and future directions for clinical translation.

Main Methods:

  • Comprehensive literature review of preclinical and clinical studies on NCs in ovarian cancer.
  • Analysis of NCs' effects on cell proliferation, apoptosis, angiogenesis, metastasis, and chemoresistance.
  • Examination of NCs' impact on key signaling pathways (PI3K/AKT/mTOR, NF-κB, MAPK, Wnt/β-catenin), epigenetics, and microRNAs.

Main Results:

  • Various NCs (quercetin, curcumin, resveratrol, EGCG, berberine, ellagic acid, withaferin A, celastrol) exhibit broad-spectrum anticancer activities against OC.
  • NCs modulate critical oncogenic pathways, epigenetics, and microRNA expression.
  • Significant preclinical evidence exists, but clinical translation is limited by bioavailability and trial design.

Conclusions:

  • Natural compounds possess significant potential as adjunct therapies for ovarian cancer.
  • Overcoming translational barriers requires advanced drug delivery, precision medicine, and sustainable sourcing.
  • Combination and personalized regimens integrating NCs may improve therapeutic outcomes and combat chemoresistance.
Keywords:
apoptosischemoresistancenanodelivery systemsnatural compoundsovarian cancer

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