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Updated: Feb 10, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

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Integrative multi-omics and experimental analyses implicate PTK2 as a lorazepam-associated biomarker and potential

Xia Hong1, Xingjun He2, Suli He1

  • 1Department of Obstetrics and Gynecology, Affiliated Hospital of Yangzhou University, Yangzhou, China.

Frontiers in Pharmacology
|February 9, 2026
PubMed
Abstract

Insights

This study reveals PTK2 as a key molecular link between lorazepam and ovarian cancer, acting as an oncogenic driver. Targeting PTK2 offers a promising strategy for ovarian cancer treatment and drug repurposing.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Ovarian cancer is a lethal gynecologic malignancy with high recurrence and chemoresistance.
  • Neuroactive drugs like lorazepam may have off-target effects in tumor biology.
  • The molecular mechanisms linking lorazepam to ovarian cancer are largely unexplored.

Purpose of the Study:

  • Identify and validate shared molecular targets of lorazepam and ovarian cancer.
  • Uncover novel biomarkers for ovarian cancer.
  • Explore new therapeutic mechanisms for ovarian cancer treatment.

Main Methods:

  • Utilized databases (CTD, STITCH, GeneCards) to identify overlapping genes.
  • Performed bioinformatic analyses including network construction and survival analysis.
  • Conducted immune infiltration, transcriptomics, and experimental validation (qPCR, cell assays).

Main Results:

  • Identified 51 overlapping genes, with PTK2 as a central hub.
  • PTK2 overexpression correlated with poor prognosis, immune activation, and metabolic changes.
  • PTK2 knockdown inhibited ovarian cancer cell proliferation, migration, and induced apoptosis.

Conclusions:

  • PTK2 acts as an oncogenic mediator linking lorazepam signaling to ovarian cancer progression.
  • PTK2 serves as a biomarker and druggable target integrating tumor growth, immunity, and metabolism.
  • Targeting PTK2 presents a potential therapeutic strategy for precision oncology and drug repurposing.
Keywords:
Ptk2drug repurposingimmunemicroenvironmentlorazepammulti-omicsovarian cancerspatial transcriptomics

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