Related Experiment Video
Updated: Feb 10, 2026
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Incidence and associated factors of major VCI in first-ever ischemic stroke patients with mild VCI: a five-year
Ho Seok Lee1, Min Kyun Sohn2, Jongmin Lee3
1Department of Physical Medicine and Rehabilitation, Chung-Ang University Hospital, Seoul, Republic of Korea.
Background:
Long-term outcomes of ischemic stroke patients having mild vascular cognitive impairment (VCI) are not well-known. The aim of this study was to investigate the five-year outcomes of ischemic stroke patients with mild VCI.
Methods:
This study analyzed data from the Korean Stroke Cohort for Functioning and Rehabilitation study. Patients were recruited from August 2012 through May 2015. We included patients who survived five-year after stroke onset and were classified as having mild VCI at six-month post-onset. Assessments were performed serially from six-month to five-year post-onset. Cognition was assessed by Korean version of Mini-Mental Status Examination (K-MMSE). Functional Independence Measure (FIM) was used to assess activities of daily living (ADL) of the participants. Vascular Impairment of Cognition Classification Consensus Study (VICCCS) guideline was used to define VCI condition. Longitudinal trajectories of VCI condition and K-MMSE, including the specific domains, were identified. Multivariable logistic regression analysis was performed, to demonstrated factors associated with progression to major VCI condition.
Findings:
A total of 998 patients were included. At five-year post-onset, 136 (13·6%) patients progressed to major VCI condition. Older age (OR 1·09, 95% CI 1·06∼1·12), presence of diabetes (OR 1·83, 95% CI 1·15∼2·88) and atrial fibrillation (OR 2·47, 95% CI 1·25∼4·79), high level of education (OR 0·32, 95% CI 0·10∼0·90), etiology of small vessel occlusion (OR 1·95, 95% CI 1·18∼3·22), higher FIM score at six-month (OR 0·90, 95% CI 0·85∼0·96), impairment in the attention and calculation domain of the K-MMSE at six-month (OR 2·10, 95% CI 1·25∼3·61), and longer hospitalization (OR 1·04, 95% CI 1·02∼1·05) were associated with the risk of being classified as having major VCI at five-year.
Interpretation:
This study investigated the incidence and associated factors of major VCI in patients with mild VCI. The results provide insights into cognitive decline trajectories in this population, enabling the development of targeted management strategies to mitigate disease progression.
Funding:
The Research Program funded by Korea Disease Control and Prevention Agency.
Related Concept Videos
01:29Factors Affecting Protein-Drug Binding: Patient-Related Factors
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
01:08Prevalence and Incidence
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
01:27Major Hormones and Their Functions
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
01:28Major Losses in Pipes
Fluid flow can be classified as laminar or turbulent, primarily based on the Reynolds number. This dimensionless number reflects the relative influence of inertial to viscous...
01:19Major Organs of the Digestive System
Gastrointestinal tract:
01:21Types of Reports II: Incident or Occurrence Report
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...