Related Experiment Video

Updated: Feb 10, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

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Carriage of multidrug-resistant bacteria and encoding genes among Vietnamese children with acute diarrhea

Xuan Duong Tran1,2,3, Thi Loi Dao3, Ndiaw Goumballa1,2

  • 1Aix Marseille Univ, AP-HM, SSA, RITMES, Marseille, France.

IJID Regions
|February 9, 2026
PubMed

Insights

Multidrug-resistant bacteria and resistance genes are common in children with acute diarrhea, indicating prior exposure. This highlights the need for better antimicrobial stewardship and infection control to combat rising resistance.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genetics

Background:

  • The increasing prevalence of multidrug-resistant (MDR) bacteria poses a significant global health threat.
  • Children, particularly those hospitalized with acute diarrhea, are a vulnerable population for carrying MDR organisms.

Purpose of the Study:

  • To determine the prevalence of MDR bacterial carriage and specific resistance-encoding genes in young children hospitalized with acute diarrhea.
  • To investigate the presence of colistin resistance genes in stool samples from these children.

Main Methods:

  • A prospective study involving 451 children under 5 years old hospitalized with acute diarrhea.
  • Stool sample analysis for MDR bacteria identification, antimicrobial susceptibility testing, and real-time PCR for resistance genes (including colistin resistance genes).

Main Results:

  • 33.2% of children carried MDR bacteria and/or colistin resistance genes.
  • MDR pathogens were found in 17.6% of children, with common isolates including Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae.
  • High resistance rates were observed for common antibiotics, and specific resistance genes (e.g., mecA, blaCTX-M-A, mcr-1) were frequently detected.

Conclusions:

  • MDR bacterial carriage and resistance genes are frequently detected upon hospital admission in children with acute diarrhea.
  • Findings suggest community or prior healthcare exposure rather than in-hospital selection.
  • Urgent need for enhanced antimicrobial stewardship, infection control, and diagnostics to address this public health challenge.
Abstract

Keywords:
Acute diarrheaAntibiotic resistantChildrenESBLMRSAMultidrug-resistant

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