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Combined Renuvion and Endolift Therapy Suggests Enhanced Skin Tightening Compared to Monotherapy in Upper Arm
Mohammadali Nilforoushzadeh1,2, Tannaz Fakhim2, Seyedeh Nasim Mirbahari1,2
1Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Introduction:
Skin laxity, a common esthetic concern, drives demand for non-surgical solutions. Energy-based devices like Renuvion® (helium plasma/radiofrequency) and Endolift® (1,470 nm diode laser) offer minimally invasive tightening, yet their combined efficacy remains underexplored. This study evaluates synergistic effects of Renuvion® and Endolift® through an intra-patient comparison.
Case Presentation:
A 44-year-old female with moderate upper arm laxity underwent Renuvion® alone on the right arm and combined Renuvion® + Endolift® on the left. Endolift® (6 W, 50 ms ON/OFF pulses, 600 μm fiber) delivered 4,000 J-5,000 J per arm via subdermal scraping. Renuvion® followed 1 week later, using standard subdermal settings. Outcomes were assessed via laxity scoring, circumferential measurements, blinded practitioner evaluations, and patient feedback at 8 weeks. The combination arm demonstrated a higher reduction in circumference (34.3% vs. 28.8%) and superior practitioner ratings (3/3 vs. 2/3), indicating enhanced skin tightening. Blinded practitioners rated the left arm's improvement as "marked" (score 3/3) vs. "moderate" (score 2/3) for the right. Patient satisfaction aligned with objective metrics, citing the left arm as "tighter" and "more contoured." No adverse events occurred.
Conclusion:
Combining Renuvion® and Endolift® enhanced skin tightening compared to Renuvion® monotherapy, which may suggest synergistic subdermal remodeling. This dual-modality approach may optimize outcomes in fibrous anatomical regions, though larger controlled studies are warranted.
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