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Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
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Exploring Cyclodextrin-Based MOFs for Drug Delivery: Synthesis, Applications, and Future Perspectives.

Şeyma Edisan1, N Başaran Mutlu-Ağardan1

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Cyclodextrin-based metal-organic frameworks (CD-MOFs) offer a biocompatible alternative to traditional MOFs. This review explores their synthesis, drug loading, and potential in drug delivery systems.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Metal-organic frameworks (MOFs) are advanced porous materials with high surface area and tunable properties, widely used in gas storage, separation, and catalysis.
  • Conventional MOFs often utilize hazardous metals and organic linkers, limiting their biomedical applications.
  • Cyclodextrin-based metal-organic frameworks (CD-MOFs) are emerging as biocompatible alternatives, synthesized from safer components like cyclodextrins and alkali metal salts.

Purpose of the Study:

  • To comprehensively review the synthesis of 3D cyclodextrin-based metal-organic frameworks (CD-MOFs).
  • To examine various drug loading methodologies for CD-MOFs.
  • To analyze the advantages and limitations of different drug loading strategies and assess the potential of CD-MOFs in drug delivery.

Main Methods:

  • Synthesis of 3D CD-MOFs using cyclodextrins as organic linkers and alkali metal salts (e.g., KOH, NaOH, KCl) as metal sources.
  • Exploration of diverse drug loading techniques applicable to CD-MOF structures.
  • Comparative analysis of different drug loading methods, evaluating their efficiency and suitability for specific applications.

Main Results:

  • CD-MOFs form body-centered cubic structures through coordination with alkali metal cations.
  • Various synthesis techniques and drug loading strategies are available for CD-MOFs.
  • CD-MOFs demonstrate significant potential for drug delivery due to their biocompatibility and tunable properties.

Conclusions:

  • 3D CD-MOFs present a promising class of biocompatible materials for advanced applications.
  • The choice of synthesis and drug loading method is crucial for optimizing CD-MOF performance in drug delivery.
  • Further research into CD-MOF synthesis and drug loading holds potential for developing novel therapeutic systems.