Related Experiment Video

Updated: Feb 10, 2026

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

2.0K

The association of biological age and its trajectory with incident heart failure: a cohort study from China

Yuhao Hu1,2, Huayu Sun2,3,4, Chenrui Zhu2

  • 1Hebei North University, Zhangjiakou, Hebei, China.

Frontiers in Cardiovascular Medicine
|February 9, 2026
PubMed

Insights

Accelerated biological aging increases heart failure (HF) risk, while decelerated aging reduces it. Consistently high biological age (BA) poses the greatest HF risk.

Area of Science:

  • Gerontology
  • Cardiovascular Medicine
  • Biostatistics

Background:

  • Biological age (BA) estimation using clinical parameters shows promise in predicting cardiovascular diseases.
  • Limited evidence exists linking BA and its trajectories to heart failure (HF) incidence.
  • This study addresses this gap by investigating the association between clinical-parameter-based BA, its trajectories, and incident HF.

Purpose of the Study:

  • To develop a clinical-parameter-based biological age (BA) model.
  • To examine the association between baseline BA status and incident heart failure (HF).
  • To investigate the impact of different biological age trajectories on HF risk.

Main Methods:

  • Utilized data from 76,908 Chinese adults in the Kailuan Study (2006-2007).
  • Employed a deep neural network model to estimate BA from 32 clinical indicators.
  • Analyzed baseline aging status (decelerated, accelerated, normal) and six aging trajectories using Cox proportional hazard models.

Main Results:

  • Accelerated aging was associated with a 30% increased HF risk (HR: 1.30).
  • A high-stable aging trajectory showed the highest HF risk (HR: 1.79).
  • A high-descending trajectory was linked to a reduced HF risk compared to the high-stable trajectory (HR: 0.74).

Conclusions:

  • Accelerated biological aging is a significant risk factor for heart failure (HF).
  • Decelerated biological aging is associated with a reduced risk of HF.
  • Individuals with consistently high biological age exhibit the highest risk for developing HF.
Abstract

Keywords:
aging trajectorybiological agecohort studyheart failurekailuan study

More Related Videos

Gene Transfer for Ischemic Heart Failure in a Preclinical Model07:35

Gene Transfer for Ischemic Heart Failure in a Preclinical Model

Published on: May 15, 2011

13.4K
A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs07:09

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Published on: February 18, 2022

2.4K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
987
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.9K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
937
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
385
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.0K
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
352