Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio in relation to erectile...

Studies have shown that many diseases can be correctly predicted by the ratio of non-high-density lipoprotein cholesterol (NHDL-C) to serum high-density lipoprotein cholesterol (HDL-C) (NHHR). However, the association between NHHR and erectile dysfunction (ED) risk is unknown. This study looked into the probable link between NHHR and ED occurrence.

This study made use of data from the National Health and Nutrition Examination Survey (NHANES), which was carried out between 2001 and 2004. The NHDL-C level was divided by the HDL-C level to calculate the NHHR. To look at the connection between ED and NHHR, the researchers employed a range of statistical techniques, such as subgroup analysis, multivariate logistic regression modeling, and smoothed curve fitting.

In the end, 3,961 individuals were enrolled for the study, 2,800 of whom did not have ED, and 1,161 of whom did. NHHR had a strong negative association with ED occurrence. For every unit increase in NHHR, the prevalence of ED fell by 9% in the fully adjusted model. Participants in the highest quartile (Q4) of the NHHR experienced a significantly lower incidence of ED than those in the lowest quartile (Q1). Curve fitting revealed a negative association between NHHR and ED; however, interaction tests and subgroup analysis demonstrated that the substantial relationships between the various subgroups of variables were independent.

Evidence points to a direct correlation between a lower incidence of ED and greater NHHR levels.