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Association Between Growth Differentiation Factor-15 and Coagulation Parameters in Male Chinese Patients With

Huan Liu1, Yongnan Lyu2, Wen Dai1

  • 1Department of Clinical Laboratory, Renmin Hospital of Wuhan University, 430060 Wuhan, Hubei, China.

Reviews in Cardiovascular Medicine
|February 9, 2026
PubMed

Insights

Growth Differentiation Factor-15 (GDF-15) levels in male coronary artery disease (CAD) patients correlate with coagulation markers. GDF-15 may indicate coagulation instability in CAD, particularly acute coronary syndrome (ACS).

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Hematology

Background:

  • Growth Differentiation Factor-15 (GDF-15) is a novel biomarker for coronary artery disease (CAD).
  • The role of GDF-15 in the hypercoagulable state of CAD is not well understood.
  • This study investigated the relationship between GDF-15 and coagulation parameters in male Chinese CAD patients.

Purpose of the Study:

  • To explore the association between serum GDF-15 levels and various coagulation parameters in male patients with CAD.
  • To determine if GDF-15 can serve as a biomarker for coagulation status in CAD.
  • To investigate GDF-15's role in different CAD subgroups, including acute myocardial infarction (AMI) and stable angina (SA).

Main Methods:

  • A cohort of 892 subjects (592 with CAD, 300 controls) was analyzed.
  • Serum GDF-15, blood cell counts, lipids, glucose, and coagulation parameters were measured.
  • Statistical analyses included Kruskal-Wallis, ANOVA, and univariate/multivariate linear regression.

Main Results:

  • GDF-15 levels were significantly higher in CAD patients (AMI and SA) compared to controls.
  • GDF-15 positively correlated with activated partial thromboplastin time (APTT) and inversely with antithrombin III (AT3) in CAD patients.
  • In AMI patients, GDF-15 was associated with APTT and monocyte count; in SA patients, it was inversely associated with AT3.

Conclusions:

  • Elevated GDF-15 in male CAD patients is linked to altered coagulation parameters.
  • GDF-15 may act as a compensatory marker for coagulation instability in CAD.
  • GDF-15 shows potential as a biomarker for assessing coagulation status in CAD, especially in ACS.
Abstract

Keywords:
acute coronary syndromecoagulationcoronary artery diseasegrowth differentiation factor-15

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