Correlations of Parathormone and Biochemical Parameters in Chronic Kidney Disease

Hyperparathyroidism due to chronic kidney disease (CKD) is a common complication characterized by elevated parathyroid hormone (PTH) levels secondary to derangements in the homeostasis of calcium and phosphorus. The aim of our study was to figure out PTH, calcium, phosphorus, and magnesium levels in CKD and the possible correlations between them and the stages of CKD.

We performed a prospective study including 217 outpatients with levels of serum creatinine out of reference range from February 2023 to July 2024. We calculated the glomerular filtration rate (eGFR) with the 2021 CKD-Epi equation using serum creatinine. We used Jamovi Statistical Software version 2.3.28. A "p" value equal to or less than 0.05 was considered statistically significant.

We had 105 females (48%) and 112 males (52%), median age 72 years (35-94yrs). We found differences in PTH and phosphorus levels between distinct stages of CKD. For PTH the differences were found between stages IIIa and IV (p<0.001), IIIb and IV (p=0.001), while for phosphorus between stages IIIa and IIIb (p=0.003), IIIa and IV (p<0.001), IIIb and IV (p=0.01). We found correlation between eGFR and PTH (r= -0.360, p=0.001), eGFR and calcium (r=0.169, p=0.015), eGFR and magnesium (r= -0.153, p=0.028), eGFR and phosphorus (r= -0.336, p<0.001).

We concluded that there is a statistically significant correlation between PTH and stages of CKD, but the strength of correlation is low, it cannot be generalized, therefore each patient with CKD must be assessed individually.