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Tenascin N contributes to spinal motor nerve morphogenesis during development.

Charles G Marcucci1,2,3, Marieke Jones4, Coleman Blanton3,5

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Tenenascin-n (Tnn), an extracellular matrix protein, is crucial for spinal motor nerve development in zebrafish. Loss of Tnn causes minor motor axon guidance defects, revealing its role in nerve assembly.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Spinal motor nerve development involves complex interactions between neurons, glia, and muscle.
  • Extracellular matrix (ECM) proteins are vital for nerve assembly but their specific roles are not fully understood.
  • Tenenascin-n (Tnn) is an ECM glycoprotein with a poorly defined function in neural development.

Purpose of the Study:

  • To investigate the role of tenascin-n (Tnn) in zebrafish spinal motor nerve development.
  • To elucidate the function of Tnn in motor axon guidance and nerve morphogenesis.

Main Methods:

  • Utilized in situ hybridization and immunohistochemistry to determine Tnn expression patterns.
  • Generated a CRISPR/Cas9 mutant allele (tnn uva96) to study Tnn function.
  • Performed in vivo imaging and morphological analysis of motor nerve development in wild-type and mutant zebrafish.

Main Results:

  • Tnn is expressed along vertical myosepta and the ventral neural tube during spinal motor nerve development.
  • Loss of Tnn function resulted in a transient increase in ectopic motor axon exit.
  • Aberrant motor axon branching was observed in the zebrafish trunk lacking Tnn.

Conclusions:

  • Tenenascin-n (Tnn) plays a previously unrecognized role in spinal motor nerve assembly.
  • Tnn contributes to the precise guidance and morphogenesis of motor axons.
  • This study expands the understanding of molecular mechanisms governing spinal motor nerve development.