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Updated: Feb 10, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
Epithelial Reprogramming and Transition during Pulmonary Bioengineering
Satoshi Mizoguchi1,2,3, Vi Lee1,2, Hahram Kim1,2
1Department of Anesthesiology, Yale School of Medicine, New Haven, CT 06520, USA.
None:
Recent research has emphasized the critical role of cell state transitions in tissue homeostasis. In lung biology, transitional cells are recognized as a feature of tissue-scale processes during both normal physiology and disease. The precise way that transitional cell states emerge and are regulated remains to be determined. Engineered tissues, built in a laboratory through bioengineering approaches, allow detailed study of cellular states that are not commonly found in native biology, and allow opportunities to directly induce and manipulate cellular transitions. The following study explores and characterizes epithelial cell states that emerge via cellular reprogramming in a tissue engineering context.
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