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Updated: Feb 10, 2026

Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
Protocol for Retinal Imaging and Extraction of Imaging-Derived Phenotypes from the Chinese Human Phenome Project
Lizhen Lan1, Binxin Xu1, Zhiqiang Yan1
1Human Phenome Institute, Fudan University, 825 Zhangheng Road, Pudong New District, Shanghai, 201203 China.
Abstract:
Retinal imaging is pivotal in the evaluation of ocular and systemic health, presenting significant promise for extensive population studies. However, the lack of standardized and automated techniques for extracting Imaging-Derived Phenotypes (IDPs) from retinal images is a major impediment. To counteract this challenge, the Chinese Human Phenome Project (CHPP) has developed a comprehensive protocol that includes Quality Control (QC), preprocessing, and automated or semi-automated extraction of IDPs from fundus photography and Optical Coherence Tomography (OCT) images. This protocol incorporates Artificial Intelligence (AI)-based methods to achieve accurate and efficient IDP extraction, facilitating standardized analysis of large-scale populations. We hope that this Standard Operating Procedure (SOP) guideline will impart valuable insights for ophthalmology-related disciplines and provides support for future research endeavors utilizing retinal imaging data.
Supplementary Information:
The online version contains supplementary material available at 10.1007/s43657-023-00155-5.
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