Related Experiment Video

Updated: Feb 10, 2026

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification
10:39

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification

Published on: November 28, 2016

11.8K

Evaluating the Link Between High-Density Lipoprotein-Related Inflammatory Indices and Gallstone Disease in U.S.

Chang Fu1, Junhong Chen1, Kai Liu1

  • 1Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, 130021, Jilin, China, jlu.edu.cn.

Mediators of Inflammation
|February 9, 2026
PubMed

Insights

High levels of HDL-related inflammatory indices, such as LHR and MHR, are linked to an increased risk of gallstone disease. These simple blood markers offer a cost-effective method for early gallstone risk assessment.

Area of Science:

  • Digestive System Health
  • Metabolic and Inflammatory Diseases
  • Biomarker Discovery

Background:

  • Gallstone disease is associated with inflammation and lipid metabolism.
  • High-density lipoprotein (HDL) related inflammatory markers are key indicators of immune response.
  • Understanding the link between HDL indices and gallstone formation is crucial.

Purpose of the Study:

  • To investigate the association between HDL-related inflammatory indices and gallstone disease.
  • To evaluate the predictive value of ratios like lymphocyte-to-HDL cholesterol (LHR) for gallstone risk.

Main Methods:

  • Utilized data from the National Health and Nutrition Examination Survey (NHANES) 2017-2020 and 2021-2023.
  • Employed weighted multivariable logistic regression and restricted cubic spline (RCS) analyses.
  • Conducted subgroup analyses to ensure result consistency across diverse populations.

Main Results:

  • A significant positive correlation was found between higher quartiles of LHR, monocyte-to-HDL cholesterol ratio (MHR), neutrophil-to-HDL cholesterol ratio (NHR), and platelet-to-HDL cholesterol ratio (PHR) and gallstone disease.
  • Elevated risk of gallstone disease was observed with increased LHR (58.6%), MHR (67.6%), NHR (68.7%), and PHR (42.7%) compared to the lowest quartile.
  • The association was stronger in females, non-diabetics, non-hypertensives, non-smokers, and alcohol consumers.

Conclusions:

  • HDL-related inflammatory indices show a positive correlation with gallstone disease in a national sample.
  • These indices, calculable from routine blood tests, provide a cost-effective tool for risk stratification.
  • Potential for early detection and large-scale screening of individuals at risk for gallstone disease.
Abstract

Keywords:
HDL-related inflammatory indicesNHANESgallstone diseaselymphocyte-to-high-density lipoprotein cholesterol ratiomonocyte-to-high-density lipoprotein cholesterol rationeutrophil-to-high-density lipoprotein cholesterol ratioplatelet-to-high-density lipoprotein cholesterol ratio

More Related Videos

Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein07:26

Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein

Published on: August 12, 2025

736
Fast and Simplified Method for High Through-put Isolation of miRNA from Highly Purified High Density Lipoprotein09:48

Fast and Simplified Method for High Through-put Isolation of miRNA from Highly Purified High Density Lipoprotein

Published on: July 27, 2016

12.4K

Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.2K
Indicators02:39

Indicators

Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...
61.1K
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.1K
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
607
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
696
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
9.7K