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Expert Consensus on the Diagnosis and Management of Inherited Hyperbilirubinemia (2025)

Sujun Zheng1, Xiaoyuan Xu2, Yuemin Nan3

  • 1Beijing YouAn Hospital, Capital Medical University, Beijing, China.

Journal of Clinical and Translational Hepatology
|February 9, 2026
PubMed

Insights

This expert consensus provides guidance for diagnosing and managing inherited hyperbilirubinemia, such as Gilbert syndrome and Crigler-Najjar syndrome. It integrates the latest clinical and research advancements for better patient care.

Area of Science:

  • Hepatology
  • Genetics
  • Internal Medicine

Background:

  • Inherited hyperbilirubinemia encompasses several conditions, including Gilbert syndrome, Crigler-Najjar syndrome, Dubin-Johnson syndrome, and Rotor syndrome.
  • Accurate diagnosis and management are crucial for patient outcomes.
  • Expert consensus is needed to standardize care based on current knowledge.

Purpose of the Study:

  • To develop an expert consensus on the diagnosis and management of inherited hyperbilirubinemia.
  • To provide clinicians with evidence-based guidance for conditions like Gilbert syndrome and Crigler-Najjar syndrome.
  • To integrate recent clinical and research findings into practical recommendations.

Main Methods:

  • Convening a multidisciplinary panel of Chinese experts in inherited and metabolic liver diseases.
  • Reviewing and integrating the latest advances in clinical practice.
  • Incorporating recent findings from basic research in the field.

Main Results:

  • Development of a comprehensive expert consensus report.
  • Guidelines cover diagnosis and management strategies for specific inherited hyperbilirubinemia conditions.
  • The consensus reflects the collective expertise of leading Chinese specialists.

Conclusions:

  • The expert consensus offers valuable support for clinicians.
  • It aims to improve the diagnosis and management of inherited hyperbilirubinemia.
  • This guidance facilitates informed decision-making in clinical practice.

Keywords:
Crigler-Najjar syndromeDubin-Johnson syndromeExpert consensusGilbert syndromeInherited hyperbilirubinemiaRotor syndrome

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