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Glucose-only Therapy for Potassium Reduction: A Scoping Review.

Samuel Ford1,2,3, Ian Coombes1,2, Julian Williams4,3

  • 1Department of Health and Behavioural Sciences, The University of Queensland, Brisbane, Australia.

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Summary
This summary is machine-generated.

Glucose-only therapy may lower potassium in non-diabetic individuals but has mixed results in those with diabetes. This approach could be an alternative to insulin-dextrose for hyperkalemia, but more research is needed.

Keywords:
Diabetes mellituselectrolyte managementendogenous insulinglucose-only therapyhyperkalemiahypoglycemiainsulinpotassiumscoping reviewserum potassium

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Area of Science:

  • Endocrinology
  • Nephrology
  • Internal Medicine

Background:

  • Insulin-dextrose is standard for hyperkalemia but risks hypoglycemia.
  • Glucose alone may stimulate insulin release, potentially reducing hypoglycemia risk.

Purpose of the Study:

  • To review studies on glucose-only therapy for serum potassium reduction in adults.
  • To assess efficacy and safety compared to insulin-dextrose therapy.

Main Methods:

  • Scoping review of oral or intravenous glucose studies without insulin.
  • Included adult human studies, excluded non-peer-reviewed and indeterminate diabetes status.
  • Narrative synthesis categorized by diabetes status and intervention type.

Main Results:

  • Glucose-only therapy generally lowered potassium in non-diabetic individuals.
  • Potassium levels often increased in insulin-dependent individuals.
  • Methodological limitations were prevalent across studies.

Conclusions:

  • Glucose-only therapy shows potential for non-diabetic hyperkalemia management.
  • Evidence for efficacy and safety in diabetic populations is inconsistent and limited.
  • Further rigorous, controlled trials are essential to clarify its role and hypoglycemia risk.