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Updated: Feb 10, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Direct NF2 functionalization of ketones: a mild strategy for accessing high-performance gem-difluoroamino compounds
Yuehui Wang1, Lele Wen1, Lin Ling1
1State Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China. wenlele@sioc.ac.cn.
Abstract:
The difluoroamino (NF2) group is a highly valuable energetic moiety. This work presents a mild method for converting aromatic ketones into novel gem-difluoramino compounds using Me4NSO3NF2. Their structures were confirmed by spectroscopy and crystallography. Compound 2k exhibits high thermal stability, lower sensitivity, and superior detonation performance, demonstrating its potential as a high-energy oxidizer.
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