Impact of Treatment Related Neutropenia on Response to Palbociclib in Metastatic Hormone Positive, her2neu Negative

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Abdelmottaleb Al Dandan1, Mohammed Alamer1, Alaa Adel Alsalman1

  • 1Department of Medical Oncology, King Fahad Hospital, Alahsa, Saudi Arabia.

Asian Pacific Journal of Cancer Prevention : APJCP
|February 9, 2026
PubMed

Insights

Cyclin-dependent kinases (CDK4/6) inhibitors like Palbociclib are crucial for metastatic breast cancer. Neutropenia, a side effect, did not negatively impact treatment outcomes in this study.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Cyclin-dependent kinases (CDK4/6) inhibitors are vital in treating metastatic hormone receptor-positive (HR+) and HER2-negative breast cancer.
  • These inhibitors target CDK4 and CDK6 proteins, which drive cell cycle progression and proliferation in cancer development.
  • Palbociclib is a key therapeutic agent for HR+, HER2- metastatic breast cancer.

Purpose of the Study:

  • To evaluate the impact of Palbociclib treatment on patients with metastatic HR+, HER2- breast cancer.
  • To assess the incidence and severity of neutropenia associated with Palbociclib therapy.
  • To determine if neutropenia and subsequent dose reductions affect disease outcomes, including progression-free survival (PFS).

Main Methods:

  • A retrospective study included 64 patients with metastatic HR+, HER2- breast cancer treated with Palbociclib.
  • Patients received Palbociclib in combination with either letrozole or fulvestrant.
  • Follow-up was conducted for a median of 30 months to assess treatment outcomes and adverse events like neutropenia.

Main Results:

  • The majority of patients (90.6%) were treated with Palbociclib and letrozole.
  • Neutropenia was observed in 87.5% of patients, with varying grades (I, II, III).
  • Dose reductions of Palbociclib occurred in 29.7% of cases; however, adjusted doses did not significantly impact outcomes, and 30-month PFS rates were high across different doses.

Conclusions:

  • Neutropenia induced by Palbociclib, even with dose adjustments, did not adversely affect disease outcomes in this patient cohort.
  • The study suggests that Palbociclib remains an effective treatment option for metastatic HR+, HER2- breast cancer, with manageable side effects.
Keywords:
CDK4/6 inhibitorsDisease outcomePalbociclibbreast cancergrades of neutropenia

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