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Updated: Feb 10, 2026
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Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit
Published on: April 15, 2021
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Risk factors for saccular unruptured intracranial aneurysms: a systematic review and meta-analysis
Maaike J A van Eldik1, Mariam Ali2, Stijn Rietkerken1
1Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
European Stroke Journal
|February 9, 2026
Summary
Hypertension and smoking are linked to a higher risk of unruptured intracranial aneurysms (UIAs). More research is needed to understand sex-specific risk factors for UIAs, as current data lacks stratification.
Area of Science:
- Neurology
- Epidemiology
- Public Health
Background:
- Unruptured intracranial aneurysms (UIAs) disproportionately affect women.
- Ruptured aneurysms cause subarachnoid hemorrhage (aSAH), but UIA risk factors are less understood.
- Systematic review and meta-analysis to identify UIA risk factors and explore sex differences.
Purpose of the Study:
- To identify key risk factors associated with the presence of saccular UIAs.
- To assess potential sex differences in these risk factors.
- To inform future research directions for UIA prevention and management.
Main Methods:
- Systematic review and meta-analysis of cohort, case-control, and cross-sectional studies.
- Inclusion of studies published up to March 2024.
- Analysis of risk factors including smoking, hypertension, alcohol use, diabetes, hypercholesterolemia, physical activity, and BMI.
Main Results:
- 21 studies with over 347,000 participants and 8,698 UIA cases were analyzed.
- Hypertension (OR 1.72) and smoking (OR 1.47) were significantly associated with increased UIA risk.
- No significant associations found for other assessed risk factors; limited sex-stratified data available.
Conclusions:
- Hypertension and smoking are confirmed risk factors for UIAs.
- The lack of sex-stratified data hinders understanding of sex-specific UIA risk profiles.
- Future research must include sex-stratified analysis to explore female-specific risk factors.
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