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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Relative Risk01:12

Relative Risk

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Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
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Transcription Factors02:16

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
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Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
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Risk Factors for Invasive Infection in Febrile Oncology Patients Related to Cancer Type.

Borja Gomez1, Oriol Quintana2, Mirian Moreno2

  • 1Department of Pediatric Emergency, Hospital Universitario Cruces, BioBizkaia Health Research Institute.

Pediatric Emergency Care
|February 9, 2026
PubMed
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In febrile pediatric oncology patients, high-risk hematologic cancers and elevated procalcitonin levels predict invasive infections. Age is a key factor for those with solid tumors.

Keywords:
biomarkersinvasive infectiononcology patients

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Area of Science:

  • Pediatric Oncology
  • Infectious Diseases
  • Emergency Medicine

Background:

  • Febrile episodes in pediatric oncology patients pose a significant risk for invasive infections.
  • Identifying specific risk factors is crucial for timely diagnosis and management in the Pediatric Emergency Department.

Purpose of the Study:

  • To determine clinical and laboratory risk factors for invasive infection in febrile pediatric oncology patients.
  • To stratify risk based on cancer type, including hematologic cancers and solid tumors.

Main Methods:

  • Prospective observational study of 471 febrile oncology patients (2016-2023).
  • Invasive infection defined microbiologically or clinically.
  • Multivariate analyses performed separately for hematologic cancers (stratified by myelotoxicity) and solid tumors.

Main Results:

  • Invasive infections occurred in 14.6% of episodes, with higher rates in high-risk hematologic cancers (23.2%).
  • For hematologic cancers, high-risk cancer type (OR: 6.006) and elevated procalcitonin (OR: 1.668) predicted invasive infection.
  • Age (OR: 1.145) was the independent risk factor for invasive infection in patients with solid tumors.

Conclusions:

  • Cancer type and procalcitonin levels are valuable predictors of invasive infection risk in febrile pediatric patients with hematologic cancers.
  • Age is a significant independent risk factor for invasive infection in pediatric patients with solid tumors presenting with fever.