Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Termination of Translation01:44

Termination of Translation

27.8K
The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
27.8K
Termination of Translation01:44

Termination of Translation

6.8K
6.8K
Standard Enthalpy of Formation02:37

Standard Enthalpy of Formation

49.3K
Enthalpy changes are typically tabulated for reactions in which both the reactants and products are at the same conditions. A standard state is a commonly accepted set of conditions used as a reference point for the determination of properties under other different conditions. For chemists, the IUPAC standard state refers to materials under a pressure of 1 bar and solutions at 1 M and does not specify a temperature. Many thermochemical tables list values with a standard state of 1 atm. Because...
49.3K
Ionic Crystal Structures02:42

Ionic Crystal Structures

17.2K
Ionic crystals consist of two or more different kinds of ions that usually have different sizes. The packing of these ions into a crystal structure is more complex than the packing of metal atoms that are the same size.
Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
17.2K
Crystal Growth: Principles of Crystallization01:25

Crystal Growth: Principles of Crystallization

5.1K
Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...
5.1K
Crystal Field Theory - Octahedral Complexes02:58

Crystal Field Theory - Octahedral Complexes

30.9K
Crystal Field Theory
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
30.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fine structural tuning of the assembly of elastin-collagen peptide conjugates with drug loading and manipulation of molecular interactions.

Biomaterials science·2026
Same author

Patchy peptide particles for pH-responsive assembly into liquid crystals or lattices.

Science (New York, N.Y.)·2026
Same author

Electrostatic Coassembly of Coiled-Coil Peptide Bundlemers with Complementary Charges into Porous 2D Lattices.

Journal of the American Chemical Society·2025
Same author

Designed coiled-coil peptide nanoparticles with tunable self-assembly: distinct ordered nanostructures <i>via</i> nonnatural side chain modification and electrostatic screening.

Soft matter·2025
Same author

Protein-Based Nanostructures: Column-free Biosynthesis of Bundlemer Peptides with Programmable, Orthogonally Reactive Handles for Nanomaterial Construction.

ACS applied materials & interfaces·2025
Same author

Thermo-reversible gelation of self-assembled conducting polymer colloids.

Nature communications·2025
Same journal

Engineered Young Brown Adipose Tissue-Derived Exosomes Alleviate Radiation-Induced Lung Injury by Promoting G Protein-Coupled Receptor 183 Ubiquitination.

ACS nano·2026
Same journal

Pore Geometry-Driven Capture of Trace Aromatic Volatile Organic Compounds in Al-Based MOFs.

ACS nano·2026
Same journal

Dual-Bridged Porphyrin-Based Covalent Organic Framework with Integrated Specific Fluorescent Recognition and Cooperative Adsorption Capabilities.

ACS nano·2026
Same journal

Split-Gate Memtransistors for Energy-Efficient Adaptive Reinforcement Learning.

ACS nano·2026
Same journal

Interface Coordination Nucleation of Copper Nanoclusters on Covalent Organic Frameworks for Electrocatalytic Ammonia Synthesis.

ACS nano·2026
Same journal

High-Performance Near-Infrared Quantum Emission from Color Centers in hBN.

ACS nano·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins
11:14

Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins

Published on: January 6, 2017

8.5K

Terminal-Directed Supramolecular Liquid Crystal Formation by Designed Coiled-Coil Interparticle Stacking.

Tianren Zhang1,2, Yi Shi1, Jacob R Schwartz1

  • 1Department of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716, United States.

ACS Nano
|February 9, 2026
PubMed
Summary
This summary is machine-generated.

Computationally designed peptides self-assemble into liquid crystal phases through programmable end-to-end stacking. This molecular design controls macroscopic properties, enabling new peptide-based materials.

Keywords:
coiled coilcomputational designinterparticle interactionliquid crystalliquid−liquid crystal phase separationmolecular simulationself-assembly

More Related Videos

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
06:44

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding

Published on: March 24, 2018

69.6K
How to Use the H1 Deep Transcranial Magnetic Stimulation Coil for Conditions Other than Depression
07:00

How to Use the H1 Deep Transcranial Magnetic Stimulation Coil for Conditions Other than Depression

Published on: January 23, 2017

24.9K

Related Experiment Videos

Last Updated: Feb 10, 2026

Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins
11:14

Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins

Published on: January 6, 2017

8.5K
From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
06:44

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding

Published on: March 24, 2018

69.6K
How to Use the H1 Deep Transcranial Magnetic Stimulation Coil for Conditions Other than Depression
07:00

How to Use the H1 Deep Transcranial Magnetic Stimulation Coil for Conditions Other than Depression

Published on: January 23, 2017

24.9K

Area of Science:

  • Biomolecular Engineering
  • Materials Science
  • Supramolecular Chemistry

Background:

  • Understanding peptide self-assembly is crucial for designing advanced materials.
  • Controlling hierarchical structures from sequence-level information is a significant challenge.

Purpose of the Study:

  • To demonstrate a simulation-guided framework for designing peptides with predictable liquid crystalline behavior.
  • To investigate the role of terminal residue interactions in peptide self-assembly and phase formation.

Main Methods:

  • Computational design of single charge-type (SC) coiled-coil peptides.
  • Experimental characterization of lyotropic liquid-crystalline (LC) phases.
  • Analysis of peptide concentration, salt effects, and terminal residue interactions.

Main Results:

  • SC coiled-coil peptides self-assemble into multiple LC phases (nematic, hexagonal columnar, smectic A, smectic B) via end-to-end stacking.
  • Terminal residue interactions (N-terminus flexibility, C-terminus attraction) dictate stacking and critical LC-forming concentration (CLC).
  • Tryptophan-mediated cross-linking enhanced the mechanical properties of the peptide liquid crystal.

Conclusions:

  • Peptide sequence-level design can predictably control macroscopic liquid crystal phase behavior.
  • End-to-end stacking of coiled-coil peptides offers a versatile strategy for de novo material design.
  • This approach provides a blueprint for engineering peptide-based materials with tailored properties.