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Understanding Bone Metabolism Biomarker Variability Across the Menstrual Cycle: A Systematic Review.

Isabel Guisado-Cuadrado1, Nuria Romero-Parra2,3, Paula Recacha-Ponce4

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This review found inconsistent evidence on whether bone metabolism biomarkers change during the menstrual cycle (MC). While some studies suggest changes in β-CTX-I, osteocalcin levels appear stable across the MC.

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Area of Science:

  • Endocrinology
  • Bone Biology
  • Reproductive Health

Background:

  • Bone metabolism is influenced by sex hormones, but in vivo data on menstrual cycle effects are inconsistent.
  • Understanding these fluctuations is crucial for interpreting bone biomarker results.

Conclusions:

  • Current evidence does not support a consistent pattern of bone metabolism biomarker fluctuations across the menstrual cycle.
  • Methodological variability, including hormone verification and participant characteristics, likely contributes to inconsistent findings.
  • Further standardized research is needed to clarify the relationship between the menstrual cycle and bone turnover markers.