Related Experiment Video
Updated: Feb 10, 2026

Author Spotlight: Exploring Cloning Techniques for Full-Length DNA Fragments
Published on: May 17, 2024
Research progress on NSP4 protein of porcine reproductive and respiratory syndrome virus
Xiaolin Lan1, Fang Liang1, Gan Li1
1Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan Guangdong, 528225, China.
Abstract:
Porcine Reproductive and Respiratory Syndrome (PRRS), caused by the PRRS virus (PRRSV), is a prevalent swine pathogen that results in reproductive and respiratory issues. The non-structural protein 4 (NSP4) of PRRSV is a 3C-like serine enzyme with a vital triad (His39-Asp64-Ser118), which is crucial for cleaving viral polyproteins pp1a and pp1ab to yield operational non-structural proteins (NSP3-NSP12). In addition to its role in viral replication, NSP4 suppresses interferon production and triggers host cellular apoptosis, thereby facilitating immune evasion and disease progression. This review provides insights into the structure and function of NSP4, which provide perspectives for enhancing PRRS management strategies and formulating more potent vaccines.
More Related Videos
Related Concept Videos
Reproductive Cloning
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
What are Viruses?
Asexual Reproduction
Overview of the Reproductive System
The gonads, or primary reproductive organs, produce gametes and sex hormones. In males, the testes produce spermatozoa and testosterone, which is responsible for developing secondary male sex characteristics, including a deeper voice, larger muscles, facial and body...
Anatomy of Respiratory System II: Lower Respiratory Tract
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....

