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Published on: August 4, 2023
A General Electrochemical C(sp3)-H Amination of Hydrocarbons Suitable for Inactive Alkanes, Alkenes and Alkynes
Zi-Ru Xu1, Hui Gao1, Pei-Long Wang1
1Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, Anhui Provincial Key Laboratory of Synthetic Chemistry and Applications, School of Chemistry and Chemical Engineering, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China.
Abstract:
The first example of the electrochemical C(sp3)-H amination of inactive hydrocarbons with sulfoximines was reported. We proposed the concept of an NH3-induced electrochemical reaction for the first time. Although the electrochemical C(sp3)-H functionalization of inactive linear hydrocarbons is difficult (especially for alkynes), this reaction is suitable for both linear and cyclic hydrocarbons; the reaction is advantageous because it is green, generates minimal waste (with H2 as the only byproduct), proceeds without transition metal and external oxidant, and requires mild reaction conditions.
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