Ten Hot Topics in Cardiovascular Risk Management for Chronic Kidney Disease

María Marques1,2, Alberto Ortiz2,3, Gregorio Romero-González4

  • 1Nephrology Department, Hospital Universitario Puerta de Hierro-Majadahonda IDIPHISA, Madrid, Spain.

Cardiorenal Medicine
|February 9, 2026
PubMed

Insights

Patients with chronic kidney disease (CKD) face high cardiovascular disease (CVD) risks, often overlooked in practice. This review addresses key questions to improve CVD risk assessment and management in CKD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Internal Medicine

Background:

  • Chronic kidney disease (CKD) significantly elevates cardiovascular disease (CVD) risk.
  • Cardiovascular risk in CKD patients is frequently underestimated and undertreated.
  • There is a need for updated, evidence-based guidance on managing CVD risk in CKD.

Purpose of the Study:

  • To address ten critical, up-to-date questions regarding cardiovascular risk in patients with CKD.
  • To provide expert nephrologists' evidence-based perspectives on managing CVD risk in CKD.
  • To synthesize current knowledge and propose practical strategies for clinical integration.

Main Methods:

  • A review format summarizing expert opinions on ten key questions.
  • Evidence-based assessment of arterial health and cardiovascular risk stratification.
  • Evaluation of pharmacological and non-pharmacological interventions for CVD risk reduction.
  • Discussion of specific management strategies including blood pressure and dyslipidemia targets.

Main Results:

  • Expert consensus on assessing arterial status and estimating cardiovascular risk in CKD.
  • Identification of key biomarkers for improved cardiovascular risk stratification.
  • Recommendations for pharmacological and non-pharmacological interventions.
  • Guidance on blood pressure goals, dyslipidemia management, and care during renal replacement therapy.

Conclusions:

  • A comprehensive approach is needed to address the elevated cardiovascular risk in CKD.
  • Integrating updated knowledge on risk assessment and management is crucial for clinical practice.
  • Proposes a unified strategy for managing cardiovascular risk in the entire CKD population.
Abstract

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