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Updated: Feb 11, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Ten Hot Topics in Cardiovascular Risk Management for Chronic Kidney Disease
María Marques1,2, Alberto Ortiz2,3, Gregorio Romero-González4
1Nephrology Department, Hospital Universitario Puerta de Hierro-Majadahonda IDIPHISA, Madrid, Spain.
Insights
Patients with chronic kidney disease (CKD) face high cardiovascular disease (CVD) risks, often overlooked in practice. This review addresses key questions to improve CVD risk assessment and management in CKD patients.
Area of Science:
- Nephrology
- Cardiology
- Internal Medicine
Background:
- Chronic kidney disease (CKD) significantly elevates cardiovascular disease (CVD) risk.
- Cardiovascular risk in CKD patients is frequently underestimated and undertreated.
- There is a need for updated, evidence-based guidance on managing CVD risk in CKD.
Purpose of the Study:
- To address ten critical, up-to-date questions regarding cardiovascular risk in patients with CKD.
- To provide expert nephrologists' evidence-based perspectives on managing CVD risk in CKD.
- To synthesize current knowledge and propose practical strategies for clinical integration.
Main Methods:
- A review format summarizing expert opinions on ten key questions.
- Evidence-based assessment of arterial health and cardiovascular risk stratification.
- Evaluation of pharmacological and non-pharmacological interventions for CVD risk reduction.
- Discussion of specific management strategies including blood pressure and dyslipidemia targets.
Main Results:
- Expert consensus on assessing arterial status and estimating cardiovascular risk in CKD.
- Identification of key biomarkers for improved cardiovascular risk stratification.
- Recommendations for pharmacological and non-pharmacological interventions.
- Guidance on blood pressure goals, dyslipidemia management, and care during renal replacement therapy.
Conclusions:
- A comprehensive approach is needed to address the elevated cardiovascular risk in CKD.
- Integrating updated knowledge on risk assessment and management is crucial for clinical practice.
- Proposes a unified strategy for managing cardiovascular risk in the entire CKD population.
Background:
Chronic kidney disease (CKD) is associated with a markedly increased risk of cardiovascular disease (CVD). Despite this, cardiovascular risk in patients with CKD is frequently underestimated and insufficiently treated in routine clinical practice.
Summary:
In this narrative review, we address ten concise and up-to-date questions focused on cardiovascular risk management in CKD. A panel of ten expert nephrologists provides evidence-based perspectives on key aspects including assessment of the arterial tree, cardiovascular risk estimation, identification of biomarkers for improved risk stratification, and both pharmacological and non-pharmacological interventions proven to reduce cardiovascular risk. Additional topics include blood pressure targets, optimal management of dyslipidemia, and cardiovascular risk management in patients receiving renal replacement therapy. Practical strategies to translate this evidence into everyday clinical care are also discussed.
Key Message:
A comprehensive and structured approach to cardiovascular risk assessment and management are essential in patients with CKD and should be systematically integrated into routine nephrology practice to improve cardiovascular outcomes.
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Assessment

