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Updated: Feb 11, 2026
08:48
Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
Published on: February 16, 2022
3.5K
Coviretinopathy: COVID-19-induced VEGF-dependent retinopathy
Xiaolu Wang1,2,3, Xu Jing1, Ziheng Guo4
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 77, Sweden.
Summary
COVID-19 causes retinopathy by inducing hypoxia and increasing VEGF, leading to retinal vascular damage. Blocking VEGF effectively treats these COVID-19-induced eye conditions, termed coviretinopathy.
Area of Science:
- Ophthalmology
- Virology
- Pathology
Background:
- COVID-19 is linked to retinal diseases, but underlying mechanisms are unclear.
- SARS-CoV-2 infection may trigger pathological changes in the retina.
Purpose of the Study:
- To investigate the link between SARS-CoV-2 infection and retinopathy development.
- To elucidate the cellular and molecular mechanisms of COVID-19-associated retinopathy.
Main Methods:
- Utilized a mouse model of COVID-19.
- Measured VEGF expression in retina and plasma.
- Assessed retinal vascular changes and effects of VEGF blockade.
Main Results:
- COVID-19 induced pulmonary and systemic hypoxia, increasing retinal VEGF.
- Elevated VEGF caused retinal neovascularization, disorganization, and leakiness.
- VEGF blockade with a neutralizing antibody prevented these vascular changes.
Conclusions:
- COVID-19-induced hypoxia drives retinopathy via VEGF.
- Coviretinopathy describes these pathological retinal changes.
- VEGF blockade offers a therapeutic strategy for coviretinopathy.
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