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Related Experiment Video

Updated: Feb 11, 2026

Evaluating the Function of the Foot Core System in the Elderly

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Published on: March 11, 2022

Review Article: YY2 in Tumor Regulation: Core Mechanisms and Functional Networks.

Yanjun Li¹, Lin Tang², Xiang Jia²

¹Chongqing University of Technology.

Critical Reviews in Oncogenesis

|February 9, 2026

Summary

This summary is machine-generated.

Ying Yang 2 (YY2) transcription factor plays dual roles in cancer, suppressing tumors by inhibiting cholesterol synthesis in liver cancer but promoting esophageal cancer by altering cell metabolism. Its functions impact cancer stem cells, stability, and immunity.

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Area of Science:

Molecular biology
Cancer research
Genetics

Background:

Ying Yang 2 (YY2) is a transcription factor structurally similar to YY1.
YY2 has context-dependent roles in various cancers, acting as both a tumor suppressor and oncogene.
Its roles in tumor biology are multifaceted, influencing metabolism, stemness, and genomic stability.

Purpose of the Study:

To systematically review the current understanding of YY2's roles in cancer.
To highlight YY2's dual functions in tumor initiation and therapy resistance.
To elucidate YY2's involvement in metabolic reprogramming, cancer stem cell maintenance, chromosomal stability, and the tumor immune microenvironment.

Main Methods:

Literature review and synthesis of existing research on YY2 in cancer.
Analysis of YY2's molecular mechanisms in different cancer types.
Comparative study of YY2's functions in hepatocellular carcinoma and esophageal carcinoma.

Main Results:

YY2 acts as a tumor suppressor in hepatocellular carcinoma by inhibiting cholesterol synthesis.
YY2 promotes esophageal carcinoma by upregulating glycolytic genes (PDHA1/PDK3), driving metabolic reprogramming.
YY2 influences cancer stem cell maintenance, chromosomal stability, and the tumor immune microenvironment.

Conclusions:

YY2 is a key transcriptional regulator with paradoxical roles in cancer progression and therapy resistance.
YY2 links metabolic pathways, genomic stability, and immune responses in cancer cells.
Understanding YY2's dual functions is crucial for developing targeted cancer therapies.